Changes of epidural blood flow after epidural administration of epinephrine in young rats

Paediatric Anaesthesia
Yukako AbukawaMakoto Ozaki

Abstract

For caudal epidural analgesia, the needle is inserted at a site where vessels are abundant. To avoid complications related to intravascular administration of the local anesthetic, epinephrine is usually added, but there is no evidence about the safety of epidural administration of epinephrine in pediatric patients. The objective of this study was to assess the changes in epidural blood flow after epidural injection of epinephrine in young rats. With approval of the local ethics committee, four young Sprague-Dawley rats weighing 110-120 g were investigated. The rats were anesthetized with isoflurane via a mask. After there was no escape reaction to pain, an arterial catheter, epidural blood flow monitor (Laser Doppler blood flow ALF 21; ADVANCE Corp.), and caudal epidural catheter were inserted while the rats remained under general anesthesia. Exactly, 10 μl of 1 : 1000 epinephrine was then infused, followed by measurement of the blood pressure and epidural blood flow. After the recovery of the blood pressure and epidural blood flow to baseline, 10 μl of saline was infused through the epidural catheter. The blood pressure and epidural blood flow were then measured again. One rat was excluded because epinephrine was inadvertently...Continue Reading

References

Jun 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Q A FisherM Yaster
Jun 29, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Manabu KakinohanaKazuhiro Sugahara
Feb 9, 2012·British Journal of Anaesthesia·M LundbladP A Lönnqvist
Aug 19, 2014·Paediatric Anaesthesia·David A AugustCharles J Coté

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