Changes of functional connectivity of the anterior cingulate cortex in women with primary dysmenorrhea
Abstract
Primary dysmenorrhea (PDM), a common gynecological disorder, is associated with structural and functional alterations in several subregions of the anterior cingulate cortex (ACC). However, systematic functional connectivity of the ACC subregions in PDM has not been clarified. In this study, we used resting-state functional magnetic resonance imaging (fMRI) data from forty-eight PDM patients and thirty-eight matched female healthy controls to investigate the functional connectivity of ACC subregions in PDM. Compared to healthy controls, PDM patients exhibited increased connectivity between the caudal ACC (cACC) and primary somatosensory cortex (SI), between the perigenual ACC (pACC) and caudate, and between the subgenual ACC (sACC) and medial prefrontal cortex (mPFC). PDM patients also showed decreased connectivity between the pACC and precuneus. In PDM group, the connectivity of the right pACC-right caudate positively correlated with disease duration, and the connectivity of the left pACC-left precuneus negatively correlated with disease severity. These present findings reveal that abnormal ACC connectivity may be implicated in the PDM-related disturbances in pain sensory, modulation, and affection. We hope that our study could...Continue Reading
References
A study of serum malondialdehyde and interleukin-6 levels in young women with dysmenorrhea in Taiwan
Effective treatment of chronic low back pain in humans reverses abnormal brain anatomy and function.
Alterations of the default mode network in functional dyspepsia patients: a resting-state fmri study
Citations
Dynamic network topological properties for classifying primary dysmenorrhoea in the pain-free phase.
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