PMID: 16529693Mar 15, 2006Paper

Changes of gene expression profile of multiple myeloma cell line RPMI 8226 treated by arsenic trioxide

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Meng-Chang WangPeng-Bo Liu

Abstract

To compare the changes of gene expression profiles of multiple myeloma cell line RPMI 8226 before and after 24-hour intervention of arsenic trioxide. The responses of the RPMI 8226 cells to arsenic trioxide were determined with cDNA microarray which included 4,096 different human genes. Of these 4,096 genes, the expressions of 273 genes were altered significantly at mRNA level. The expressions of 121 genes were up-regulated while the expressions of 152 genes were down-regulated. The effect of arsenic trioxide on RPMI 8226 cells is related to changing the expression levels of a number of genes. ZFYVE16, ALK1 and TXNIP genes may play important roles in apoptosis and differentiation of RPMI 8226 cells.

References

Sep 25, 1998·The Journal of Biological Chemistry·K IwabuchiS Fields
May 30, 2001·FEBS Letters·S MatsudaC Berthet
Sep 8, 2001·The Journal of Biological Chemistry·L F Seet, W Hong
Nov 14, 2003·The Journal of Biological Chemistry·Li-Fong SeetWanjin Hong
Mar 23, 2004·Biochemical and Biophysical Research Communications·Kenji IwaiMitsuhiro Yokoyama
Jan 20, 2005·Journal of Cell Science·Li-Fong Seet, Wanjin Hong

❮ Previous
Next ❯

Citations

Mar 4, 2017·International Journal of Molecular Sciences·Mohammed H RashedCristian Rodriguez-Aguayo
Jan 28, 2017·Cell Proliferation·Hong-Yu GaoDong-Sheng Pei
Mar 6, 2012·Phytotherapy Research : PTR·Shuli ManChangxiao Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Meng-Chang WangPeng-Bo Liu
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
Xiu-Jie ZhouWen-Bin Qian
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
Cui-Lian LiHai-Bo Zhang
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
Yun LiangRong-Zhen Xu
© 2021 Meta ULC. All rights reserved