Changes of global gene expression and secondary metabolite accumulation during light-dependent Aspergillus nidulans development

Fungal Genetics and Biology : FG & B
Ozgür BayramGerhard H Braus

Abstract

Fungal development and secondary metabolite production are coordinated by regulatory complexes as the trimeric velvet complex. Light accelerates asexual but decreases sexual development of the filamentous fungus Aspergillus nidulans. Changes in gene expression and secondary metabolite accumulation in response to environmental stimuli have been the focus of many studies, but a comprehensive comparison during entire development is lacking. We compared snapshots of transcript and metabolite profiles during fungal development in dark or light. Overall 2.014 genes corresponding to 19% of the genome were differentially expressed when submerged vegetative hyphae were compared to surface development. Differentiation was preferentially asexual in light or preferentially sexual connected to delayed asexual development in dark. Light induces significantly gene expression within the first 24-48h after the transfer to surfaces. Many light induced genes are also expressed in dark after a delay of up to two days, which might be required for preparation of enhanced sexual development. Darkness results in a massive transcriptional reprogramming causing a peak of lipid-derived fungal pheromone synthesis (psi factors) during early sexual developm...Continue Reading

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Citations

Jun 27, 2017·Fungal Genetics and Biology : FG & B·Julia Schumacher
Nov 1, 2018·Nature Reviews. Microbiology·Zhenzhong Yu, Reinhard Fischer
Mar 4, 2020·International Journal of Molecular Sciences·Anna PawlikGrzegorz Janusz
Apr 13, 2018·Microbiology and Molecular Biology Reviews : MMBR·Meritxell RiquelmeReinhard Fischer
Jan 16, 2019·International Journal of Molecular Sciences·Anna PawlikGrzegorz Janusz
Jan 15, 2017·Microbiology Spectrum·Reinhard FischerLuis M Corrochano
Dec 22, 2016·Journal of Agricultural and Food Chemistry·Liling WangFusheng Chen
Nov 17, 2021·Molecular Ecology·Tania Chavarria-PizarroSilke Werth

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