PMID: 16647006May 2, 2006Paper

Changes of hemodynamics during establishment of animal model of acute myocardial infarction induced by ligation of left coronary artery in goat

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Xiao-bin WangXian-ling Tang

Abstract

To study the changes in hemodynamics in experimental acute myocardial infarction induced by ligation of the left coronary artery in goat. Animal model of acute myocardial infarction was reproduced in 20 goats by ligation of the left coronary artery through xyphoid process. ST segment of electrocardiogram (ECG), mean artery blood pressure (MAP), central venous pressure (CVP), and heart rate (HR) were observed before, immediately, 30 minutes, 1 hour and 2 hours after ligation of the left coronary artery. ECG of all goats was normal before operation. Immediately and 30 minutes after ligation, elevation of ST-segment was seen in 8 and 10 goats respectively, and in 18 goats elevation of ST-segment was observed 2 hours after ligation. Four weeks after the operation, pathological Q wave was shown in the chest leads of ECG in 18 goats. There was no significant difference in MAP, CVP and HR between before and after ligation. Frequent ventricular premature beats were found in 6 goats, but they were stopped after intravenous infusion of lidocaine. Small area of experimental acute myocardial infarction in goats shows slight effect on hemodynamics, though the production of myocardial infarction is reliable, and the life of the goats could b...Continue Reading

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