Changes of inflammatory cytokines/chemokines during ravidasvir plus ritonavir-boosted danoprevir and ribavirin therapy for patients with genotype 1 b hepatitis C infection

Journal of Medical Virology
Lanlan XiaoLanjuan Li

Abstract

0BJECTIVE: This study investigated the safety and efficacy of ravidasvir (RDV) plus ritonavir-boosted danoprevir (DNVr) and ribavirin (RBV) regimens for treatment-naïve non-cirrhotic patients with hepatitis C virus (HCV) genotype 1b in mainland China. We also gained insight into HCV-host interactions during anti-HCV treatment. 16 HCV patients and 10 healthy people enrolled the study. 3 of 16 patients received 12-weeks' placebo treatment first and served as the placebo controls. All (n=16) patients received 12-weeks' RDV plus DNVr and RBV treatment. The adverse effects (AEs), viral loads, alanine transaminase (ALT) and aspartate aminotransferase (AST) were recorded during study. We also performed multianalyte profiling of 48 cytokines/chemokines in 16 HCV patients and 10 normal controls. 75% patients treated with RDV plus DNVr and RBV experienced AEs. No death, treatment-related serious AEs or AEs leading to discontinuation were reported. The serum HCV-RNA levels remained extremely high in 3 placebo controls after treated with placebo. After RDV plus DNVr and RBV treatment, all patients achieved sustained virologic response (SVR) at post-treatment week 12, but 1 patient experienced viral relapse at SVR 24. The cytokine/chemokine...Continue Reading

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Citations

Jul 13, 2021·Antimicrobial Agents and Chemotherapy·Guolan WuJianzhong Shentu

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