Changes of motor corticobulbar projections following different lesion types affecting the central nervous system in adult macaque monkeys

The European Journal of Neuroscience
Michela FregosiE M Rouiller

Abstract

Functional recovery from central nervous system injury is likely to be partly due to a rearrangement of neural circuits. In this context, the corticobulbar (corticoreticular) motor projections onto different nuclei of the ponto-medullary reticular formation (PMRF) were investigated in 13 adult macaque monkeys after either, primary motor cortex injury (MCI) in the hand area, or spinal cord injury (SCI) or Parkinson's disease-like lesions of the nigro-striatal dopaminergic system (PD). A subgroup of animals in both MCI and SCI groups was treated with neurite growth promoting anti-Nogo-A antibodies, whereas all PD animals were treated with autologous neural cell ecosystems (ANCE). The anterograde tracer BDA was injected either in the premotor cortex (PM) or in the primary motor cortex (M1) to label and quantify corticobulbar axonal boutons terminaux and en passant in PMRF. As compared to intact animals, after MCI the density of corticobulbar projections from PM was strongly reduced but maintained their laterality dominance (ipsilateral), both in the presence or absence of anti-Nogo-A antibody treatment. In contrast, the density of corticobulbar projections from M1 was increased following opposite hemi-section of the cervical cord ...Continue Reading

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Citations

Jul 10, 2019·Annual Review of Neuroscience·Ludwig Ruder, Silvia Arber
May 28, 2019·Frontiers in Neurology·Sheng LiWilliam Zev Rymer

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Methods Mentioned

BETA
SMA
biopsies
biopsy

Software Mentioned

Neurolucida
OsiriX

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