Changes of MR and DTI appearance in early human brain development

Proceedings - Society of Photo-Optical Instrumentation Engineers
Cassian MarcMartin Styner

Abstract

Understanding myelination in early brain development is of clinical importance, as many neurological disorders have their origin in early cerebral organization and maturation. The goal of this work is to study a large neonate database acquired with standard MR imagery to illuminate effects of early development in MRI. 90 neonates were selected from a study of healthy brain development. Subjects were imaged via MRI postnatally. MR acquisition included high-resolution structural and diffusion tensor images. Unbiased atlases for structural and DTI data were generated and co-registered into a single coordinate frame for voxel-wise comparison of MR and DTI appearance across time. All original datasets were mapped into this frame and structural image data was additionally intensity normalized. In addition, myelinated white matter probabilistic segmentations from our neonate tissue segmentation were mapped into the same space to study how our segmentation results were affected by the changing intensity characteristics in early development Linear regression maps and p-value maps were computed and visualized. The resulting visualization of voxels-wise corresponding maps of all MR and DTI properties captures early development information...Continue Reading

Citations

Nov 19, 2015·Frontiers in Neuroanatomy·Rajiv DeshpandeKenichi Oishi

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