Changes of multiple biotransformation phase I and phase II enzyme activities in human fetal adrenals during fetal development

Acta Pharmacologica Sinica
Hui WangJun-yan Hong

Abstract

Fetal adrenal, which synthesizes steroid hormones, is critical to fetal growth and development. Our recent research showed that some xenobiotics could interfere with steroidogenesis and induce intrauterine growth retardation in rats. The study on the characteristics of biotransformation enzymes in fetal adrenals still seems to be important with respect to possible significance in xenobiotic-induced fetal development toxicity. In this study, the activities of several important xenobiotic-related phase I and phase II enzymes in human fetal adrenals were examined and compared with those in fetal livers. The activity and mRNA expression were determined by enzymatic analysis and RT-PCR. The levels of cytochrome (CYP)2A6, CYP2E1, and CYP3A7 isozymes in fetal adrenals were 82%, 92%, and 33% of those in fetal livers, respectively. There was a good positive correlation between adrenal CYP2A6 activity and gestational time. The values of alpha glutathione S-transferase (GST), pi-GST, and microGST in adrenals were 0.5, 4.4, and 8.3-fold of those in the livers, respectively, and the activity of adrenal pi-GST was negatively correlated with gestational time. The uridine diphosphoglucuronyl transferase activities, which were measured using p-...Continue Reading

References

Jan 1, 1991·Methods in Enzymology·R M Philpot
Oct 20, 1995·Journal of Chromatography. B, Biomedical Applications·P SanwaldJ Dow
Jul 29, 1998·Chemico-biological Interactions·S Ouwerkerk-Mahadevan, G J Mulder
Jan 7, 1999·FEBS Letters·M L van IerselP J van Bladeren
Feb 9, 2000·Pharmacology & Therapeutics·J A RingD J Morgan
Feb 28, 2002·Clinical Obstetrics and Gynecology·Gerald G Briggs
Jan 22, 2003·Advanced Drug Delivery Reviews·Amber M YoungKenneth L Audus
Jan 15, 2004·Cancer Science·Tsutomu Shimada, Yoshiaki Fujii-Kuriyama
Feb 6, 2004·Biochemical Pharmacology·Travis T DentonJohn R Cashman
Jun 2, 2004·Clinical Pharmacokinetics·Michael R SymeJeffrey A Keelan
Sep 24, 2004·Basic & Clinical Pharmacology & Toxicology·Stefan Wilkening, Augustinus Bader
Nov 24, 2004·Drug Metabolism Reviews·Dharamainder ChoudharyJohn B Schenkman
Jan 7, 2005·Seminars in Reproductive Medicine·William E RaineyBruce R Carr
Feb 11, 2005·Seminars in Fetal & Neonatal Medicine·Michael J BlakeGregory L Kearns
Apr 16, 2005·Annual Review of Pharmacology and Toxicology·Minor J Coon
Aug 23, 2005·Cancer Letters·Yuki TsuchiyaTsuyoshi Yokoi
Sep 21, 2007·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Man ChenHui Wang

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Citations

Dec 3, 2014·Biochemical Pharmacology·Diana L ShusterQingcheng Mao
Jul 20, 2010·Biochimica Et Biophysica Acta·Ina NeunzigMatthias Bureik
Jun 29, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Martin HillLuboslav Stárka
Feb 18, 2015·Basic & Clinical Pharmacology & Toxicology·Stina BettsLena Ekström

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