Changes of noradrenergic activity and lipolysis in the subcutaneous abdominal adipose tissue of hypo- and hyperthyroid patients: an in vivo microdialysis study

Annals of the New York Academy of Sciences
Jara NedvidkovaKarel Pacak

Abstract

Thyroid function plays an important role in the regulation of overall metabolic rate and lipid metabolism. However, it is uncertain whether thyroid hormones directly affect lipolysis in adipose tissue and to what extent those changes contribute to overall metabolic phenotype. Our study was designed, using the microdialysis technique, to determine basal and isoprenaline-stimulated local lipolysis and to determine local concentrations of lipolysis-regulating catecholamines in abdominal subcutaneous adipose tissue in 12 patients with hypothyroidism, 6 patients with hyperthyroidism, and 12 healthy control subjects. Plasma norepinephrine (NE) concentrations in hypothyroid subjects were significantly higher than in the control and hyperthyroid groups. In contrast, systemic, adipose NE levels in hypothyroid patients were decreased relative to controls. Hyperthyroidism, on the other hand, resulted in four-fold higher adipose NE levels. Basal lipolysis measured by glycerol concentrations in adipose tissue was significantly attenuated in hypothyroid patients and markedly increased in hyperthyroid patients in comparison with the control group. In addition to differences in basal lipolysis, hypothyroidism resulted in attenuated, and hypert...Continue Reading

References

Apr 1, 1994·The Journal of Clinical Endocrinology and Metabolism·H WahrenbergP Arner
Jan 1, 1997·Hormone Research·B Richelsen
Jun 8, 2000·Annals of the New York Academy of Sciences·C LondosC M Rondinone
Feb 24, 2001·Nature·C M SteppanM A Lazar
Mar 15, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D LanginM Lafontan
Nov 14, 2001·Reviews in Endocrine & Metabolic Disorders·G A Brent
Jan 18, 2002·Nature·Yasuhiko MinokoshiBarbara B Kahn
May 30, 2002·Thyroid : Official Journal of the American Thyroid Association·Leonidas H Duntas
Oct 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Anne Lene Dalkjaer RiisNiels Møller

❮ Previous
Next ❯

Citations

Jun 27, 2008·Thyroid : Official Journal of the American Thyroid Association·Debora Lucia Seguro DanilovicSuemi Marui
May 9, 2013·European Journal of Endocrinology·Jonathan M Hazlehurst, Jeremy W Tomlinson
May 10, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Adam M Rotunda, Michael S Kolodney
Jun 1, 2014·Life Sciences·Su Jin ChungJi Hoon Jeong
Mar 29, 2006·Journal of Pharmacological and Toxicological Methods·Christian HöchtCarlos A Taira
Apr 9, 2014·International Journal of Endocrinology·Agnieszka KozaczAndrzej Wojciech Ziemba
Mar 17, 2018·The Journal of Clinical Endocrinology and Metabolism·Thomas LangeMaik Pietzner
Jul 10, 2010·Thyroid : Official Journal of the American Thyroid Association·Signe GjeddeNiels Møller
Jun 4, 2010·Endocrine Reviews·Panayota MitrouGeorge Dimitriadis
Jan 18, 2006·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Adam M RotundaAlison Sharpe Avram
May 15, 2020·Endocrine·Agnieszka KozaczAndrzej Wojciech Ziemba
Mar 7, 2021·Biomedicines·Manon MoreauNathalie Janel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.