PMID: 8584412Nov 1, 1995Paper

Changes of pH affect calcium currents but not outward potassium currents in rat myometrial cells

Pflügers Archiv : European journal of physiology
A V ShmigolD A Eisner

Abstract

Spontaneous contraction of uterine smooth muscle is enhanced by alkalinization and depressed by acidification. We have investigated the ionic currents responsible for this in single myometrial cells. Intracellular acidification (20 mM butyrate) at constant external pH depressed the magnitude of the calcium current to 58+/-6% of control, but had little effect on outward currents. Similar but slower effects were also observed when the extracellular pH was lowered to 6.9 (56+/-9% of control). Correspondingly, when the intracellular or extracellular pH was elevated (20 mM NH4Cl or pH 7.9 respectively) the calcium current magnitude increased (165+/-15% in NH4Cl; 136+/-2% at pH 7.9) and there was, again, no effect on the outward currents. These observations are consistent with the effects of pH on spontaneous contractile activity being due to an effect on the membrane calcium current.

References

Oct 1, 1991·Pflügers Archiv : European journal of physiology·H MiyoshiA Fujiwara
Apr 1, 1994·The Journal of General Physiology·U Klöckner, G Isenberg
Jun 1, 1993·Pflügers Archiv : European journal of physiology·M Taggart, S Wray

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Citations

Oct 1, 1995·Pflügers Archiv : European journal of physiology·J R ParrattS Wray
Sep 1, 1996·Pflügers Archiv : European journal of physiology·M J TaggartS Wray
Jul 27, 1999·The Journal of Physiology·J Larcombe-McDouallS Wray
Aug 21, 2015·Experimental Physiology·Susan Wray
Mar 14, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Theodor BurdygaSusan Wray
May 12, 1998·The Journal of Physiology·M J Taggart, S Wray
May 1, 2007·Experimental Physiology·Susan Wray
Dec 10, 2013·Experimental Physiology·Sarah ArrowsmithSusan Wray
Nov 25, 1997·American Journal of Obstetrics and Gynecology·M J TaggartS Wray
Apr 25, 2003·American Journal of Obstetrics and Gynecology·S Joanne PierceSusan Wray
Jun 8, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Eva Wiberg-ItzelHelena Åkerud
Nov 13, 2002·American Journal of Physiology. Heart and Circulatory Physiology·R D SmithSusan Wray

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