Changes of Plasma FABP4, CRP, Leptin, and Chemerin Levels in relation to Different Dietary Patterns and Duodenal-Jejunal Omega Switch Surgery in Sprague-Dawley Rats

Oxidative Medicine and Cellular Longevity
Dominika StygarKonrad Wojciech Karcz

Abstract

Pathophysiological links between inflammation, obesity, and adipokines can be used for the treatment of metabolic dysregulation. To examine the influence of duodenal-jejunal omega switch surgery in combination with different diet patterns on plasma concentrations of fatty acid-binding protein 4 (FABP4), C-reactive protein (CRP), leptin, and chemerin. After 8 weeks on a high-fat diet (HF) or control diet (CD), rats underwent surgery. Duodenal-jejunal omega switch (DJOS) with an exclusion of one-third of intestinal length and SHAM surgery were performed. For the next 8 weeks, 50% of DJOS/SHAM animals were kept on the same diet as before (HF/DJOS/HF, HF/SHAM/HF, CD/DJOS/CD, and CD/SHAM/CD), and 50% had a changed diet (HF/DJOS/CD, HF/SHAM/CD, CD/DJOS/HF, and CD/SHAM/HF). FABP4, CRP, leptin, and chemerin were assessed using ELISA kits. FABP4: significant differences between DJOS and SHAM were observed in animals maintained on CD/CD; CRP: varied between DJOS and SHAM groups maintained on HF/HF, CD/CD, and CD/HF; leptin and chemerin levels: DJOS lowered leptin and chemerin plasma levels versus SHAM, while HF/HF, CD/HF, and HF/CD significantly increased leptin and chemerin plasma levels when compared to CD/CD. The beneficial effect of ...Continue Reading

References

Nov 1, 2002·Annals of Surgery·Francesco Rubino, Michel Gagner
Oct 8, 2003·The Journal of Experimental Medicine·Valérie WittamerDavid Communi
Oct 14, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antonio La CavaGiuseppe Matarese
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Valérie WittamerDavid Communi
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Jan 11, 2007·Archives of Internal Medicine·Elizabeth SelvinThomas P Erlinger
Sep 5, 2007·Biochemical and Biophysical Research Communications·Sang-gun RohShin-ichi Sasaki
May 31, 2008·Nature Reviews. Drug Discovery·Masato Furuhashi, Gökhan S Hotamisligil
Sep 23, 2008·Journal of Clinical Laboratory Analysis·D StejskalJ Bronsky
Nov 26, 2008·Nature Reviews. Immunology·Gökhan S Hotamisligil, Ebru Erbay
Dec 18, 2008·Nutrition Research Reviews·L Kirsty ForsytheM Barbara E Livingstone
Jun 2, 2009·The American Journal of Medicine·Michael A Nauck
Jun 30, 2009·Clinical Endocrinology·Johanna WeigertChrista Buechler
Dec 8, 2009·Endocrinology·Arvind BatraBritta Siegmund
Aug 19, 2010·The Journal of Biological Chemistry·Judith Storch, Alfred E Thumser
Aug 20, 2010·The Journal of Clinical Endocrinology and Metabolism·Ana B CrujeirasFelipe F Casanueva
Sep 8, 2010·Trends in Endocrinology and Metabolism : TEM·Matthew C Ernst, Christopher J Sinal
Nov 26, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Barham K Abu DayyehChristopher C Thompson
Jan 12, 2011·Annual Review of Immunology·Margaret F Gregor, Gökhan S Hotamisligil
Dec 20, 2011·Molecular Genetics and Metabolism·Geneviève FaucherMarie-Claude Vohl
Jan 4, 2012·Proteomics. Clinical Applications·Stefan LehrHenrike Sell
Nov 1, 2012·The British Journal of Nutrition·Line K JohnsonJøran Hjelmesæth
Nov 23, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J ChoiL Pilote
Jan 19, 2013·Arquivos brasileiros de endocrinologia e metabologia·Gilberto Paz-FilhoJulio Licinio
Feb 5, 2013·Critical Care : the Official Journal of the Critical Care Forum·Chi-Lun HuangWei-Shiung Yang
Jul 10, 2013·Nature Reviews. Gastroenterology & Hepatology·Alexander D Miras, Carel W le Roux
Aug 28, 2013·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K B ComerfordS E Karakas
Feb 7, 2014·Wideochirurgia i inne techniki mało inwazyjne = Videosurgery and other miniinvasive techniques·W Konrad KarczJodok M Grueneberger
Apr 15, 2014·BMC Surgery·Jodok Matthias GruenebergerW Konrad Karcz
Sep 4, 2014·JAMA : the Journal of the American Medical Association·Nancy PuzziferriEdward H Livingston
May 23, 2015·Life Sciences·Ana B CrujeirasFelipe F Casanueva
Mar 15, 2016·Biochemical and Biophysical Research Communications·Chen HuangJian V Zhang
Jun 9, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H Frikke-SchmidtR J Seeley

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Methods Mentioned

BETA
Assay
ELISA
gastric bypass

Software Mentioned

STATISTICA

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