PMID: 3768383Oct 24, 1986Paper

Changes of plasma lipids and long-chain n-3 and n-6 fatty acids in plasma, liver, heart and kidney phospholipids of rats fed variable levels of fish oil with or without cholesterol supplementation

Biochimica Et Biophysica Acta
Y S HuangD F Horrobin

Abstract

Diets supplemented with 10% by weight of oil, either wholly safflower oil or proportinally (25, 50, 75 or 100%) replaced by fish oil, were given to 60 rats which had previously been deprived of dietary fat for 6 weeks. Half the animals on each dietary regimen were also given 1% of cholesterol. After 4 weeks of feeding, the plasma lipid contents and the phospholipid fatty acid compositions of plasma, liver, heart and kidney were determined. In general, the concentrations of plasma lipids were significantly reduced in animals fed a diet containing 5% or more of fish oil in comparison with those fed only safflower oil. Cholesterol feeding increased the levels of plasma cholesterol, whereas it lowered those of plasma triacylglycerols and phospholipids. The levels of 20:4(n - 6) in all four tissues were sharply reduced, whereas those of 18:2(n - 6) increased when 25% of dietary safflower oil was replaced by fish oil. Both 18:2(n - 6) and 20:4(n - 6) were decreased as the contents of dietary fish oil were further increased. The levels of long-chain n-3 fatty acids, e.g., 20:5(n - 3), 22:5(n - 3) and 22:6(n - 3) were increased as the intake of fish oil increased. The incorporation of 22:6(n - 3) was greater in plasma, liver and heart ...Continue Reading

References

Feb 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·Y S HuangM S Manku
May 9, 1985·The New England Journal of Medicine·D KromhoutC de Lezenne Coulander
May 9, 1985·The New England Journal of Medicine·B E PhillipsonD R Illingworth
Mar 8, 1974·Molecular and Cellular Biochemistry·R R Brenner
Dec 1, 1982·Journal of Nutritional Science and Vitaminology·N Iritani, S Fujikawa
Sep 1, 1981·The American Journal of Clinical Nutrition·H C Bronsgeest-SchouteA Ruiter
Jan 1, 1981·Progress in Lipid Research·H Sprecher
Jan 1, 1981·Progress in Lipid Research·N W Schoene, D Fiore
Aug 1, 1954·Proceedings of the Society for Experimental Biology and Medicine·E H AHRENST T TSALTAS
Jan 1, 1952·The Journal of Clinical Endocrinology and Metabolism·L W KINSELL, H LISSER

❮ Previous
Next ❯

Citations

Dec 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K KobaY S Huang
Apr 24, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·W C TuR A Gibson
Jan 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J M BourreM Piciotti
Feb 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Y S HuangD F Horrobin
Oct 1, 1990·Journal of Dairy Science·K J Jenkins, J K Kramer
Oct 1, 1990·European Journal of Clinical Investigation·H BarrosA Nilsson
Jan 1, 1989·Journal of Internal Medicine. Supplement·K S BjerveK Bønaa
Apr 1, 1988·Nutrition Reviews·C D Berdanier
Jun 1, 1996·Zeitschrift für Ernährungswissenschaft·A Rosenquist, G Hølmer
Jun 15, 1988·Biochimica Et Biophysica Acta·J M BourreH Lafont
Apr 26, 1989·Biochimica Et Biophysica Acta·J L Zevenbergen, U M Houtsmuller
Aug 25, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·L FontanaA Gil

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.