PMID: 6540185Jun 1, 1984Paper

Changes of proliferation kinetics after X-irradiation of a human malignant melanoma grown in nude mice

European Journal of Cancer & Clinical Oncology
M Spang-Thomsen, L L Vindeløv

Abstract

A human malignant melanoma grown in nude mice was exposed to single-dose X-irradiation and the effect on the proliferation kinetics was investigated by two methods. Flow cytometric DNA analysis was performed on tumour tissue obtained by sequential fine-needle aspirations after the treatment to monitor the initial cell cycle distribution changes. The technique of labelled mitoses was used to examine the kinetics of the tumours during regrowth. The results showed that the treatment initially induced a partial synchronization of small fractions of cells accumulated in the G2 phase of the cell cycle and a dose-dependent decrease of the cell generation time due to a shortening of the G1 duration time during regrowth of the tumours. Furthermore, it was shown that the calculated values of growth fraction and cell loss factor became unreliable because the tumours contained a dose-related increasing proportion of radiation-inactivated tumour cells.

References

May 1, 1975·Comparative Biochemistry and Physiology. A, Comparative Physiology·G S MacleanP C Withers
Aug 1, 1979·International Journal of Radiation Oncology, Biology, Physics·L A Dethlefsen
Jan 1, 1971·Cell and Tissue Kinetics·G G Steel, S Hanes
Jul 1, 1984·Cell and Tissue Kinetics·M Spang-Thomsen, L L Vindeløv
Mar 1, 1983·Cytometry·L L VindeløvN I Nissen
Sep 1, 1982·Cell and Tissue Kinetics·E K RofstadT Lindmo
Jan 1, 1980·Experimental Cell Biology·M Spang-ThomsenJ Visfeldt

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Citations

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·B Maurer-SchultzeM Harasim
Nov 1, 1989·Breast Cancer Research and Treatment·M Spang-ThomsenN Brünner
Mar 28, 1998·Breast Cancer Research and Treatment·K Rygaard, M Spang-Thomsen
Jun 1, 1987·Ophthalmology·J B Crawford, D H Char
Jan 1, 1986·Acta Radiologica. Oncology·E K Rofstad
Oct 1, 1990·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E K RofstadJ M Nesland
Mar 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J M JandaR A Brenden
Jan 19, 2008·Journal of Aquatic Animal Health·Natalie D MylniczenkoForrest A Young
Jan 1, 1988·European Journal of Haematology. Supplementum·L L Vindeløv, I J Christensen

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