PMID: 3868Jan 1, 1976

Changes of protein metabolism following irradiation. II. Protease activity, protease pattern, protein and free amino acids in the cytoplasm and cell organelles of the rat liver following 600 R whole-body irradiation

Strahlentherapie
G Valet

Abstract

The protease activity of cytoplasm and cell organelles of the rat liver against liver protein and hemoglobin as a substrate increases during an initial reaction phase on the first day after 600 R whole body X-irradiation. This is probably a consequence of the degradation of cellular debris. The protein, the protease activity and the free amino acids of the cytoplasm and the cell organelles decrease during the disease phase on day 3 and 4 after irradiation. The protein loss of the liver is therefore not explained by an increased protease activity. The protease activity and the free amino acids are increased in the cytoplasm and the cell organelles during the regeneration phase of the organism between day 15 and 18 after irradiation.

Related Concepts

Protoplasm
Hydrogen-Ion Concentration
Liver
Organoids
Peptide Hydrolases
Effects of Radiation

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