Changes of renal sinus fat and renal parenchymal fat during an 18-month randomized weight loss trial

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Hila ZelichaIris Shai

Abstract

Data regarding the role of kidney adiposity, its clinical implications, and its dynamics during weight-loss are sparse. We investigated the effect of long-term weight-loss induced intervention diets on dynamics of renal-sinus-fat, an ectopic fat depot, and %renal-parenchymal-fat, lipid accumulation within the renal parenchyma. We randomized 278 participants with abdominal obesity/dyslipidemia to low-fat or Mediterranean/low-carbohydrate diets, with or without exercise. We quantified renal-sinus-fat and %renal-parenchymal-fat by whole body magnetic-resonance-imaging. Participants (age = 48 years; 89% men; body-mass-index = 31 kg/m2) had 86% retention to the trial after 18 months. Both increased renal-sinus-fat and %renal-parenchymal-fat were directly associated with hypertension, and with higher abdominal deep-subcutaneous-adipose-tissue and visceral-adipose-tissue (p of trend < 0.05 for all) after adjustment for body weight. Higher renal-sinus-fat was associated with lower estimated-glomerular-filtration-rate and with higher microalbuminuria and %HbA1C beyond body weight. After 18 months of intervention, overall renal-sinus-fat (-9%; p < 0.05 vs. baseline) but not %renal-parenchymal-fat (-1.7%; p = 0.13 vs. baseline) significan...Continue Reading

Associated Clinical Trials

Feb 10, 2012·Iris Shai

Citations

Sep 1, 2019·Magma·Karlinde A SpitDaniel H van Raalte
May 21, 2019·Journal of Cellular Physiology·Daniele FerraraFederico Carbone
Jan 12, 2019·F1000Research·Joshua Thurman, Faikah Gueler
Oct 28, 2021·Journal of Diabetes·Christian Mende, Daniel Einhorn

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