PMID: 6111823Jan 1, 1981Paper

Changes of response to dopaminergic drugs in rats submitted to REM-sleep deprivation

Psychopharmacology
S Tufik

Abstract

Three experiments were performed in order to add further support to the hypothesis that the exaggerated aggressiveness elicited by apomorphine in REM sleep deprived rats was due to a state of supersensitivity of post-synaptic dopaminergic receptors in brain. In the first experiment, REM deprived rats displayed much aggressiveness when challenged with 10 and 20 mg/kg of bromocriptine and piribedil. Thus, the intensification of responses by REM sleep deprivation is not restricted to apomorphine, as it was also obtained with two other dopaminergic agonists. In the second experiment, the association of REM deprivation with an injection of haloperidol 24 h before apomorphine administration induced still more aggressive behavior when compared to the rats that were only sleep deprived. It has been claimed that 24 h after haloperidol a state of supersensitivity to dopamine agonists occurs in the brain; therefore, it is probable that REM deprivation could also act similarly. The third experiment showed that haloperidol administered 2 h before apomorphine administration blocked the aggressive behavior in rats either submitted to REM deprivation alone or to REM deprivation plus a previous injection of haloperidol 24 h before. This also fa...Continue Reading

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Citations

Apr 29, 1986·European Journal of Pharmacology·H M Barros, J R Leite
Jun 1, 1995·Physiology & Behavior·D C Hipólide, S Tufik
Jul 1, 1995·Physiology & Behavior·S TufikD Suchecki
Apr 1, 1983·Pharmacology, Biochemistry, and Behavior·R Santos, E A Carlini
Apr 1, 1983·Pharmacology, Biochemistry, and Behavior·J FarberB A McMillen
Feb 1, 1988·Pharmacology, Biochemistry, and Behavior·R Santos, E A Carlini
Dec 1, 1993·Pharmacology, Biochemistry, and Behavior·A HamdiC Prasad
Sep 1, 1995·Pharmacology, Biochemistry, and Behavior·J W BrockC Prasad
Nov 1, 1995·Pharmacology, Biochemistry, and Behavior·L L LoboS Tufik
Jan 1, 1987·Behavioural Brain Research·R Bell, P G Hepper
Aug 1, 1996·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J Harro, L Oreland
Nov 26, 2003·Physiology & Behavior·Monica L AndersenSergio Tufik
Aug 23, 2003·Brain Research·Monica Levy Andersen, Sergio Tufik
Aug 18, 2001·Pharmacology, Biochemistry, and Behavior·M R FerrazR Santos
Jan 1, 1989·Behavioral and Neural Biology·J Velazquez-MoctezumaM L Cruz
Jan 1, 1992·Pharmacology & Toxicology·G SerraG L Gessa
Mar 30, 2012·Neuropsychobiology·Jennifer Rodríguez-VázquezJavier Velázquez-Moctezuma
Mar 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ninad GujarMatthew P Walker
Jul 30, 2014·Neuroscience Letters·L F BerroR Frussa-Filho
Aug 19, 2008·Neurobiology of Learning and Memory·Tathiana A AlvarengaSergio Tufik
Mar 11, 2008·Behavioural Brain Research·Juliana C PerrySergio Tufik
Aug 25, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Juliana C PerrySergio Tufik
Jul 17, 2007·Physiology & Behavior·Daniela Fukue FukushiroRoberto Frussa-Filho
Jun 5, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Monica L AndersenSergio Tufik
Feb 8, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Monica L AndersenSergio Tufik
Apr 20, 2005·Behavioural Brain Research·Monica Levy AndersenSergio Tufik

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