Changes of serum and peritoneal inflammatory mediators in laparoscopic radical resection for right colon carcinoma

Journal of Minimal Access Surgery
Pengcheng ZhuChungen Xing

Abstract

The objective of this study is to investigate the effects of laparoscopic and open operation on serum and peritoneal inflammatory mediators in patients with right colon carcinoma. A total of 100 patients were randomly divided into laparoscopic group (n = 50) and open group (n = 50). The age, sex, operation time, operation blood loss, post-operative Dukes stage, time to first passage of flatus and post-operative hospital stay were recorded. The levels of hypersensitive C reactive protein (hsCRP) and tumour necrosis factor-α (TNF-α) in serum and abdominal exudate were measured by ELISA at the time of pre-operative 2 h and post-operative 6 h and 24 h. There was no significant difference in age, sex, Dukes stage and pre-operative inflammatory mediators between the two groups (P > 0.05). The operation time, intraoperative blood loss, time to first passage of flatus and post-operative hospital stay were significantly better in laparoscopic group than those in open operation group. At 6 h and 24 h after operation, the levels of hsCRP and TNF-α in serum and abdominal exudate in laparoscopic group were significantly lower than those in open operation group. Laparoscopic surgery for the treatment of right colon carcinoma has the advantag...Continue Reading

References

Oct 5, 2010·Surgical Oncology Clinics of North America·Gaetano Luglio, Heidi Nelson

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Citations

Oct 5, 2018·Journal of Translational Medicine·Jennifer PasquierArash Rafii

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Methods Mentioned

BETA
dissect
ELISA

Software Mentioned

SPSS

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