Changes of serum cytokines in hyperthyroid Graves' disease patients at diagnosis and during methimazole treatment

Neuroimmunomodulation
Ana Beatriz B PedroKyoko Takei

Abstract

Cytokines are involved in the pathogenesis of Graves' disease (GD), but ambiguous serum cytokine results have been described. We studied the changes in serum interleukin (IL)-1β, soluble IL-2 receptor (sIL-2R), IL-5, IL-6 and tumor necrosis factor (TNF)-α concentrations in 29 untreated GD patients before and after restoration of euthyroidism with methimazole (MMI) treatment compared to 25 control subjects. Eleven out of 29 GD patients had active Graves' ophthalmopathy (GO). Compared to controls, untreated GD patients had significantly higher median levels of serum IL-1β (18.7 vs. 34.0 pg/ml), sIL-2R (292.5 vs. 1,585.0 pg/ml), IL-5 (1.0 vs. 9.0 pg/ml), IL-6 (3.0 vs. 5.0 pg/ml) and TNF-α (8.1 vs. 16.0 pg/ml). In euthyroidism following MMI treatment, concentrations of IL-1β (25.0 pg/ml), sIL-2R (362.0 pg/ml), IL-5 (3.0 pg/ml), IL-6 (3.0 pg/ml) and TNF-α (5.0 pg/ml) declined significantly and were similar to controls. The greatest reductions were noted in sIL-2R (76.9%), TNF-α (68.8%) and IL-5 (66.6%) levels. Serum sIL-2R, IL-5 and TNF-α levels in active GO patients were significantly elevated, but no significant differences were observed in GD patients without GO. Using a multiple linear regression analysis, serum IL-1β was signif...Continue Reading

Citations

Dec 24, 2013·The Journal of Endocrinology·Flavia Fonseca BloiseValéria de Mello-Coelho
Jan 6, 2016·Thyroid : Official Journal of the American Thyroid Association·Lianye LiuBingyin Shi
Apr 25, 2013·Advances in Medical Sciences·A Popławska-KitaM Górska
Sep 29, 2015·Thyroid : Official Journal of the American Thyroid Association·Danilo VillagelinLaura S Ward
Aug 7, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C-H LinS-R Shih
Sep 20, 2012·Arquivos brasileiros de endocrinologia e metabologia·Renata Loureiro MorettoJoão Hamilton Romaldini
May 14, 2021·European Thyroid Journal·Yuan LiXiaohui Guo

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