PMID: 42529Jan 1, 1979

Changes of serum testosterone and of LH-RH test after treatment of cryptorchidism by intranasal LH-RH

Endocrinologia Experimentalis
J SponaM von der Ohe

Abstract

The aim of the present investigation was to study, in a collaborative double-blind study, the treatment with intranasal LH-RH application of boys aged 1 1/2 to 12 years, who suffered from unilateral or bilateral cryptorchidism. A total of 88 subjects were randomly and blindly allocated to LH-RH and placebo therapy. Before and after 4 weeks of treatment basal testosterone serum levels were estimated and LH-RH tests were performed. Intranasal treatment with LH-RH resulted in partial or complete descents of testes in 23 out of 88 patients, whereas the position of testes remained unchanged in 17 subjects. 42 boys did not respond to placebo therapy, but complete descents were observed in 6 boys of the placebo group. Hormone analysis data of 4 different laboratories were recorded and statistically evaluated. No changes of LH, FSH and testosterone were found in the placebo groups. Only patients of the Frankfurt group responded to LH-RH test with augmented LH release after therapy (P less than 0.05). All patients treated with intranasal LH-RH showed a significant decrease of FSH release after therapy (P less than 0.05 to P less than 0.01). Basal testosterone serum levels were found to be increased after therapy only in the patients tre...Continue Reading

Related Concepts

Follicle-stimulating Hormone Deficiency, Isolated
Luteozyman
Follicle Stimulating Hormone
Sterotate
Administration, Intranasal
Unilateral Cryptorchidism
Gonadorelin Hydrochloride
Double-Blind Method

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