Changes of synapses in experimental autoimmune encephalomyelitis by using Fasudil

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Jie-zhong YuBao-Guo Xiao

Abstract

The ROCK signaling pathway is involved in numerous fundamental cellular functions such as cell migration, apoptosis, inflammatory responses, and neurite outgrowth. Previous studies demonstrate that Fasudil exhibited therapeutic potential of experimental autoimmune encephalomyelitis (EAE) possibly through immune-modulation and anti-inflammation. In this study, we observed the effect of Fasudil on synaptic protection of EAE mice. Fasudil ameliorated the clinical severity of EAE and inhibited Rho kinase (ROCK), especially ROCK II, in brain and spinal cord of EAE mice. Protein extracts from spinal cord of Fasudil-treated EAE mice promoted the formation of neurite outgrowth when co-cultured with primary neurons, indicating that peripheral administration of Fasudil can enter the central nervous system (CNS) and exhibited its biological effect on the formation of neurite outgrowth. Synapse-related molecule synaptophysin was enhanced, and CRMP-2, AMPA receptor, and GSK-3β were declined in spinal cord of Fasudil-treated mice. Neurotrophic factor BDNF and GDNF as well as immunomodulatory cytokine IL-10 in spinal cord were elevated in Fasudil-treated mice, while inflammatory cytokine IL-17, IL-1β, IL-6, and TNF-α were obviously inhibited,...Continue Reading

References

Dec 1, 1995·Cell and Tissue Research·L G Eshkind, R E Leube
Jun 10, 1998·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·M AmanoK Kaibuchi
Sep 28, 2000·The New England Journal of Medicine·J H NoseworthyB G Weinshenker
Jul 31, 2001·Nature Neuroscience·N InagakiK Kaibuchi
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Leila Tarsa, Yukiko Goda
Dec 14, 2002·Brain Research·Joo Kyung SungJohn H Zhang
Mar 20, 2004·Experimental & Molecular Medicine·Su-Jin KimChang-Dae Bae
Dec 29, 2004·Lancet Neurology·Per Soelberg Sorensen
Nov 2, 2005·Molecular and Cellular Biology·Nariko ArimuraKozo Kaibuchi
Apr 6, 2006·The Journal of Biological Chemistry·Fumiaki MimuraToshihide Yamashita
Apr 26, 2006·Brain : a Journal of Neurology·Manuel A FrieseLars Fugger
Jul 5, 2007·Advances in Experimental Medicine and Biology·Eric F Schmidt, Stephen M Strittmatter
Sep 7, 2007·Journal of Neuropathology and Experimental Neurology·Jeroen J G GeurtsPaul van der Valk
Sep 29, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·André SchmandkeStephen M Strittmatter
Oct 11, 2007·Brain Pathology·Jia NewcombeTerence Smith
Apr 1, 2008·Brain : a Journal of Neurology·N L SicotteS Y Bookheimer
Oct 22, 2008·Expert Review of Neurotherapeutics·Maria Pia AmatoEmilio Portaccio
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Diego CentonzeGianvito Martino
Feb 17, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Marina O ZiehnRhonda R Voskuhl
Aug 31, 2010·Cytoskeleton·Mutsuki AmanoKozo Kaibuchi
Mar 5, 2011·Multiple Sclerosis : Clinical and Laboratory Research·David BakerSandra Amor
Mar 30, 2011·Annals of Neurology·Ranjan DuttaBruce D Trapp
Oct 25, 2011·Neuroscience Letters·Jian-ying ShenHong-yang Zhao
Apr 17, 2013·Nature Reviews. Neurology·Heather Wood
Jun 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Guang YangWen-Biao Gan
Jun 19, 2013·Neuropharmacology·Horia Pribiag, David Stellwagen
Oct 25, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Junko TaniguchiHiroshi Ito
May 3, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gil M LewitusDavid Stellwagen
Jun 15, 2014·Journal of Alzheimer's Disease : JAD·Sarah B MartinElizabeth Head
Oct 20, 2014·The Cerebellum·Georgia MandolesiDiego Centonze
Nov 7, 2014·Frontiers in Neuroscience·Yuki Fujita, Toshihide Yamashita
Nov 12, 2014·Current Medicinal Chemistry·Chung-Ching ChioChing-Ping Chang
Nov 19, 2014·CNS & Neurological Disorders Drug Targets·Ti-Fei YuanOscar Arias-Carrión

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Citations

Oct 23, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Katherine J SellersRichard Killick
May 28, 2019·CNS Neuroscience & Therapeutics·Jing WangCun-Gen Ma

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