PMID: 9637162Jun 24, 1998Paper

Changes of the interleukin-6 levels in skin at different sites after thermal injury

The Journal of Trauma
M KawakamiY Okada

Abstract

To delineate the regulation of IL-6 production in unburned skin adjacent to a burn in an animal model. In C57BL/6 mice, at 15, 30, and 60 minutes after a 20% full-thickness burn, skin was removed from various sites. Control samples were obtained from unburned mice. Normal skins were incubated with tumor necrosis factor-alpha (TNF-alpha), interleukin-1 alpha (IL-1alpha), IL-1 beta, and IL-6. Unburned skin specimens were incubated with anti-TNF-alpha and IL-1alpha antibodies. Cytokine levels were measured by enzyme-linked immunosorbent assay. The burn increased the IL-6 levels at 30 minutes (p < 0.05) and the IL-1alpha levels at 15 and 60 minutes in the unburned skin. TNF-alpha, IL-1alpha, and IL-1beta increased IL-6 production in normal skin (p < 0.05). Anti-IL-1alpha antibody decreased IL-6 production in the unburned skin (p < 0.05). IL-1alpha modulates IL-6 production in unburned skin after injury. IL-6 and IL-1alpha might contribute to the alterations after a burn.

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Citations

Mar 10, 2010·Immunology and Cell Biology·Mahesh BandaraVivienne Elizabeth Reeve
Mar 29, 2006·Journal of Burn Care & Research : Official Publication of the American Burn Association·Adam J SingerMarcia Simon
Sep 20, 2005·BMC Surgery·Lars SteinstraesserStewart C Wang
Jan 19, 2008·World Journal of Gastroenterology : WJG·Bing-Wei SunXi Chen
Sep 26, 2000·Alcoholism, Clinical and Experimental Research·A ColantoniE J Kovacs
Jun 12, 2004·The Journal of Investigative Dermatology·Xu-Ping WangEhrhardt Proksch
Sep 8, 2004·International Immunopharmacology·Jun LiangYayi Hou

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