Changes of tRNA population during compensatory cell proliferation: differential expression of methionine-tRNA species

Archives of Biochemistry and Biophysics
D Kanduc

Abstract

Changes of tRNA species, as both relative percentage of total tRNA and absolute concentration, occur during liver cell proliferation induced by partial hepatectomy. Transfer RNAs which are abundant under quiescence are found to decrease during hepatocyte proliferation, and vice versa. One consequence of these changes is the differential expression of methionine-isoaccepting tRNA species. Initiator tRNA(Met) is present in scarce amounts under quiescent conditions and increases during cell-cycle progression. Elongator tRNA(Met) shows the opposite behavior. Both the quantitative and qualitative tRNA changes return to control levels as the liver returns to resting conditions. These changes might have mechanistic implications in modulating the protein synthesis required by cell proliferation. Moreover, the increase of initiator tRNA(Met) species might be necessary to translate protooncogene, growth factor, and receptor mRNAs, the translation of which is hindered by inhibitory AUG triplets upstream from the coding sequence. Thus the tRNA changes described herein could be involved in regulating translation of transcripts encoding cell-cycle associated proteins.

Citations

Feb 17, 2010·Virus Genes·Nancy M CladelNeil D Christensen
Feb 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Valérie HaurieMartin Teichmann
Apr 3, 2010·Nucleic Acids Research·Gong ZhangZoya Ignatova
Jun 10, 2010·Nucleic Acids Research·Rhodri Saunders, Charlotte M Deane
Jul 16, 2013·Journal of Bacteriology·Laasya SamhitaUmesh Varshney
Nov 21, 2009·FEBS Letters·Sarah E Kolitz, Jon R Lorsch
Sep 26, 2017·Biophysics Reviews·Mónica MarínRicardo Ehrlich
Nov 29, 2015·Biochemical Society Transactions·Iolanda Ferro, Zoya Ignatova
Jan 11, 2019·International Journal of Molecular Sciences·Jing ZhaoGong Zhang
Aug 26, 2021·Global Medical Genetics·Darja Kanduc

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