Changes of white blood cells, immunosuppressive acidic protein, and interleukin-2 receptor after open heart surgery

The Thoracic and Cardiovascular Surgeon
S H ChuK T Chen

Abstract

There are a lot of immunological changes after major surgery, especially in open heart surgery when blood flows through a cardiopulmonary bypass system. We monitored leukocyte count, lymphocyte subpopulation count, soluble IL- 2 receptor (sIL-2r) and serum IL-2 levels, and an immunosuppressive acidic protein (IAP) level before and on the 1st, 7th, and 14th day after open heart surgery. It was noted that there were significant increases of total leukocyte and granulocyte counts for more than two weeks. But total lymphocyte, T-lymphocyte, b-lymphocyte, natural killer cell, suppressor T-cell, and helper T-cell all showed significant decreases in absolute numbers for more than one week as compared to the preoperative values. Serum IAP level was elevated for more than two weeks after operation. Serum IL-2 decreased but serum sIL-2R increased in the postoperative period. It is concluded that there is a period of immunosuppression after open heart surgery which lasts for at least one week and perhaps more than two weeks.

Citations

Jul 27, 2001·Clinical and Experimental Immunology·A Roth-IsigkeitM Seyfarth
Jun 17, 2010·World Journal of Surgical Oncology·Panagiotis DedeiliasSerafim Klimopoulos
Jul 9, 2003·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·J LuoZ Sun
Nov 20, 2008·Journal of Cardiac Surgery·Panagiotis DedeiliasDimitrios Malovrouvas
May 4, 2001·Perfusion·A SablotzkiI Friedrich
May 16, 2000·Critical Care Medicine·G J DespotisP Barnes
Dec 24, 2005·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·B GaszE Roth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.