Changes over lactation in breast milk serum proteins involved in the maturation of immune and digestive system of the infant

Journal of Proteomics
Lina ZhangKasper A Hettinga

Abstract

To objective of this study was to better understand the biological functions of breast milk proteins in relation to the growth and development of infants over the first six months of life. Breast milk samples from four individual women collected at seven time points in the first six months after delivery were analyzed by filter aided sample preparation and dimethyl labeling combined with liquid chromatography tandem mass spectrometry. A total of 247 and 200 milk serum proteins were identified and quantified, respectively. The milk serum proteome showed a high similarity (80% overlap) on the qualitative level between women and over lactation. The quantitative changes in milk serum proteins were mainly caused by three groups of proteins, enzymes, and transport and immunity proteins. Of these 21 significantly changed proteins, 30% were transport proteins, such as serum albumin and fatty acid binding protein, which are both involved in transporting nutrients to the infant. The decrease of the enzyme bile salt-activated lipase as well as the immunity proteins immunoglobulins and lactoferrin coincide with the gradual maturation of the digestive and immune system of infants. The human milk serum proteome didn't differ qualitatively bu...Continue Reading

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Citations

Apr 25, 2016·Breast Cancer Research and Treatment·Jeanne MurphyKathleen F Arcaro
Mar 2, 2019·Nutrients·Mohèb ElwakielKasper A Hettinga
Feb 6, 2017·Proteome Science·Lina ZhangKasper Hettinga
Aug 11, 2019·Nutrients·Jing Zhu, Kelly A Dingess
Jan 10, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Veronica CaldeoAlan L Kelly
Mar 6, 2021·Frontiers in Nutrition·Josep Bassaganya-RieraMauro Serafini
Sep 4, 2021·Journal of Agricultural and Food Chemistry·Lina ZhangPeng Zhou
Dec 28, 2021·Physiological Reports·Vaksha PatelJun Wheeler
Feb 2, 2022·Journal of Proteome Research·Pieter M DekkerKasper A Hettinga

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