Changes over time in cognitive and structural profiles of head injury survivors.

Neuropsychologia
C H SalmondB J Sahakian

Abstract

Survivors of traumatic head injury often suffer chronic cognitive deficits. Considerable evidence implicates the cholinergic system in these deficits. Recently, we reported cognitive and structural abnormalities in a cohort of head injured survivors consistent with this hypothesis [see Salmond, C. H., Chatfield, D. A., Menon, D. K., Pickard, J. D., & Sahakian, B. J. (2005). Cognitive Sequelae of Head Injury: Involvement of Basal Forebrain and associated structures. Brain, 128(1), 189-200]. The stability of the cognitive and structural MRI profiles was investigated in a longitudinal study. Twenty-one survivors of moderate-severe head injury completed two comprehensive neuropsychological assessments and two structural MRI scans at least six months apart. A cohort of controls also completed these investigations. The results revealed that the cognitive and structural profiles are relatively stable from six months post-injury forward up to 3 years post-injury. Deficits in memory, attention and reaction time were found, with relative preservation of working memory, consistent with abnormalities in the cholinergic system. These findings suggest that cholinergic enhancers may be an effective treatment for cognitive deficits post-head i...Continue Reading

References

Jul 20, 2001·The Journal of Head Trauma Rehabilitation·S R MillisJ H Ricker
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Sep 19, 2003·Current Psychiatry Reports·David B Arciniegas

❮ Previous
Next ❯

Citations

Dec 23, 2008·Archives of Physical Medicine and Rehabilitation·Christine TillRobin E Green
Oct 16, 2012·Journal of Neurotrauma·Cameron B JeterPramod K Dash
Feb 12, 2011·Brain : a Journal of Neurology·Virginia F J NewcombeDavid K Menon
Jan 25, 2014·Brain Injury : [BI]·Anna Ostberg, Olli Tenovuo
Mar 15, 2011·The International Journal of Neuropsychopharmacology·Ahmed D Mohamed, Barbara J Sahakian
Jun 10, 2015·Neuroscience and Biobehavioral Reviews·Jane L Mathias, Patricia Wheaton
Jul 15, 2017·Brain Injury : [BI]·Juliane LauerEmmanuel A Stamatakis
Jan 7, 2017·The Journal of Head Trauma Rehabilitation·Bhanu SharmaMichael G Hutchison
Sep 4, 2018·Emergency Medicine Australasia : EMA·Catherine M LunterVirginia Fj Newcombe
Aug 10, 2017·Journal of Speech, Language, and Hearing Research : JSLHR·Karine MarcotteSheila MacDonald
Aug 6, 2020·Frontiers in Human Neuroscience·Emily L MorrowMelissa C Duff

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

© 2022 Meta ULC. All rights reserved