Changes over time in risk of initial virological failure of combination antiretroviral therapy: a multicohort analysis, 1996 to 2002

Archives of Internal Medicine
Fiona C LampeA N Phillips

Abstract

Triple-combination antiretroviral therapy (CART) for human immunodeficiency virus infection has been in use for almost a decade, but the extent to which treatment success has changed is uncertain. We examined risk of initial virological failure of CART according to the year of starting therapy. We included subjects from 5 complete clinic cohorts in Europe and Canada who started CART without previous antiretroviral therapy from 1996 to 2002 with 1 or more pre-CART viral load (VL) measurement and CD4 count. Based on the first VL measurement from 6 to 12 months after CART initiation, virological failure was defined as a VL of more than 500 copies/mL. We used the following 3 inclusion strategies: (1) including all subjects, with missing VL measurement counted as virological failure (n = 3825; strategy A); (2) including all subjects with VL measurement (n = 3120; strategy B); and (3) including all subjects receiving antiretroviral therapy at VL measurement (n = 2890; strategy C). From 1996 to 2002, risk of virological failure fell from 38.9% to 24.8% for strategy A, 28.4% to 12.0% for strategy B, and 22.8% to 8.2% for strategy C. Estimated relative reductions in risk (95% confidence interval) over the 7-year period, adjusted for coh...Continue Reading

Citations

Jan 16, 2007·BMJ : British Medical Journal·Andrew N PhillipsJens D Lundgren
Nov 14, 2008·AIDS·Andrew N PhillipsJens D Lundgren
Oct 23, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Steven G DeeksRichard D Moore
Sep 17, 2010·PloS One·Chara E RydzakUNKNOWN CEPAC Investigators
Jul 19, 2011·PloS One·Prema MenezesJoseph J Eron
Aug 5, 2011·American Journal of Epidemiology·Alison G AbrahamUNKNOWN North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AID
Jun 6, 2007·Current HIV/AIDS Reports·Joel E Gallant
Aug 8, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A MocroftUNKNOWN Opportunistic Infections Working Group on behalf of the Collaboration of Observational HIV Epidemiological Research Europe (
Dec 15, 2006·Current Medical Research and Opinion·Marie-Pierre de Béthune, Kurt Hertogs
Oct 20, 2010·HIV Medicine·B LedergerberUNKNOWN Swiss HIV Cohort Study
Jan 25, 2011·HIV Medicine·E MartínezJ M Gatell
Jul 26, 2015·Health Economics Review·Marta Trapero-Bertran, Juan Oliva-Moreno
May 3, 2007·Expert Opinion on Pharmacotherapy·Priscilla BiswasAdriano Lazzarin
May 8, 2015·AIDS Research and Human Retroviruses·Nikos PantazisUNKNOWN AMACS
Apr 23, 2015·PloS One·Fumiyo NakagawaAndrew N Phillips
Aug 11, 2007·AIDS·Andrew N PhillipsUNKNOWN UK Collaborative HIV Cohort Study
Aug 28, 2007·AIDS·Amanda MocroftUNKNOWN EuroSIDA study group and the Swiss HIV Cohort Study
Oct 13, 2007·Nature Reviews. Drug Discovery·Charles Flexner
Sep 1, 2006·Current Opinion in HIV and AIDS·Anton Pozniak
Sep 1, 2006·Current Opinion in HIV and AIDS·Paul E Sax
Nov 1, 2006·Current Opinion in HIV and AIDS·Andrew N PhillipsJens D Lundgren
Jun 4, 2008·AIDS·Rebecca K LodwickAndrew N Phillips
Jan 4, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·UNKNOWN UK Collaborative HIV Cohort (CHIC) Study Steering Committee
Nov 1, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kholoud PorterUNKNOWN UK CHIC Study Group

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