Changes to oral anticoagulant therapy and risk of death over a 3-year follow-up of a contemporary cohort of European patients with atrial fibrillation final report of the EURObservational Research Programme on Atrial Fibrillation (EORP-AF) pilot general registry

International Journal of Cardiology
Giuseppe BorianiEORP-AF Pilot General Registry Investigators

Abstract

Contemporary European data regarding patients with atrial fibrillation (AF) allow us to assess the use of oral anticoagulants (OACs) and long-term outcomes. Patients with AF presenting to cardiologists in 9 European Society of Cardiology participating countries were enrolled and followed-up for 3-years. Among the 2119 patients (40.4% female; mean age 69 ± 11 years) the prevalent types of AF at baseline were first-detected (30.5%) and paroxysmal AF (27.0%). The composite of stroke/TIA/peripheral embolism/all-cause death at 3-years occurred in 18.2%, with first detected AF and permanent AF reporting the highest event rates (22.5% and 27.3%, respectively; p < 0.0001). Age, diabetes mellitus, heart failure, restrictive cardiomyopathy, chronic kidney disease and no physical activity were significant predictors of all-cause death. Paroxysmal and persistent AF patients were more likely to be hospitalised than other types of AF (34.1% and 37.9%, p < 0.0001). At follow-up, OAC drugs were used in 80.1% of patients, with non-vitamin K antagonists (NOACs) accounting for 24.3% of patients. OAC treatment at follow-up visits changed throughout time, with a shift from VKA to NOACs reported in 5.4% of the cases, while the reverse shift (from NO...Continue Reading

Citations

Nov 15, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Christian Torp-PedersenUNKNOWN External Reviewers
Jun 15, 2020·European Journal of Clinical Investigation·Lorenzo FalsettiAlessandro Capucci
Oct 3, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Marco ProiettiUNKNOWN ESC-EORP Atrial Fibrillation General Long-Term Registry Investigators Group
Nov 9, 2020·Internal and Emergency Medicine·Vincenzo Livio MalavasiGiuseppe Boriani
Aug 28, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Marco ProiettiUNKNOWN ESC-EHRA EORP-AF Long-Term General Registry Investigators
Sep 24, 2021·European Heart Journal. Quality of Care & Clinical Outcomes·Marco ProiettiGregory Y H Lip
Aug 6, 2021·British Journal of Clinical Pharmacology·Adane Teshome KefaleLuke R Bereznicki
Nov 11, 2021·European Journal of Clinical Investigation·Alejandro I Pérez CabezaFrancisco Marín

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