Changes with age in the distribution of a frailty index

Mechanisms of Ageing and Development
Kenneth RockwoodArnold Mitnitski

Abstract

Models of human mortality include a factor that summarises intrinsic differences in individual rates of ageing, commonly called frailty. Frailty also describes a clinical syndrome of apparent vulnerability. In a representative, cross-sectional, Canadian survey (n = 66,589) we calculated a frailty index as the mean accumulation of deficits and previously showed it to increase exponentially with age. Here, its density function exhibited a monotonic change in shape, being least skewed at the oldest ages. Although the shape gradually changed, the frailty index was well fitted by a gamma distribution. Of note, the variation coefficient, initially high, decreased from middle age on. Being able to quantify frailty means that health risks can be summarised at both the individual and group levels.

Citations

Apr 21, 2007·Aging Clinical and Experimental Research·Xiaowei SongKenneth Rockwood
Feb 21, 2006·Aging Clinical and Experimental Research·David JonesKenneth Rockwood
Sep 29, 2005·Zeitschrift für Gerontologie und Geriatrie·C C Sieber
Sep 17, 2013·Journal of Medical Systems·Kevin C TsengYu-Hao Chuang
Apr 24, 2012·Age and Ageing·Roman Romero-Ortuno, Rose Anne Kenny
Jul 20, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kenneth Rockwood, Arnold Mitnitski
Jul 20, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kenneth RockwoodArnold Mitnitski
Oct 9, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Qian-Li XueLinda P Fried
Feb 7, 2009·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Danan GuZeng Yi
Sep 27, 2012·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·M Kristen PeekKenneth J Ottenbacher
Apr 11, 2009·BMJ : British Medical Journal·Matthew E DupreZeng Yi
Feb 3, 2007·Postgraduate Medical Journal·Frank Lally, Peter Crome
Aug 20, 2005·Neuroepidemiology·Xiaowei SongKenneth Rockwood
Nov 6, 2009·BMC Geriatrics·José Juan García-GonzálezLuis Miguel Gutiérrez-Robledo
Feb 25, 2011·Critical Care : the Official Journal of the Critical Care Forum·Robert C McDermidSean M Bagshaw
Sep 1, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kenneth RockwoodArnold Mitnitski
Nov 23, 2013·Australian Health Review : a Publication of the Australian Hospital Association·Melanie N HaleyAnne E Holland
Mar 24, 2009·Annales de cardiologie et d'angéiologie·P-H DucluzeauP-L Prost
Sep 21, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jocelyne C WhiteheadSusan E Howlett
Sep 20, 2011·Best Practice & Research. Clinical Anaesthesiology·Robert C McDermid, Sean M Bagshaw
Nov 26, 2010·Clinics in Geriatric Medicine·Carlos O Weiss
Sep 30, 2008·Archives of Gerontology and Geriatrics·Robert Weale
Nov 22, 2007·Journal of Shoulder and Elbow Surgery·Michael LeeFrederick Matsen
Nov 14, 2007·Journal of the American Medical Directors Association·Kenneth RockwoodArnold Mitnitski
Jan 30, 2007·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hiroaki Fukuda, Motohiko Mikasa
May 6, 2006·International Journal of Geriatric Psychiatry·Elissa AspKenneth Rockwood
Aug 21, 2008·Australasian Journal on Ageing·Iman RiddaRaina C MacIntyre
Jun 1, 2007·Journal of the American Geriatrics Society·Alexander M KulminskiAnatoli I Yashin
Jan 10, 2006·Journal of the American Geriatrics Society·Arnold MitnitskiKenneth Rockwood
Jul 25, 2013·Geriatrics & Gerontology International·Roman Romero-Ortuno
Aug 8, 2015·Neuropsychology Review·Ana M Daugherty, Naftali Raz
Mar 19, 2015·Journal of the American Medical Directors Association·Kieran A McCaulLeon Flicker
Oct 9, 2015·Current Opinion in Nephrology and Hypertension·Clara BohmNavdeep Tangri
Sep 19, 2006·Mechanisms of Ageing and Development·Alexander KulminskiKenneth Manton
Mar 8, 2006·Mechanisms of Ageing and Development·Arnold MitnitskiKenneth Rockwood
Feb 21, 2006·Mechanisms of Ageing and Development·Kenneth Rockwood, Arnold Mitnitski
Nov 1, 2005·Mechanisms of Ageing and Development·Arnold Mitnitski, Kenneth Rockwood
May 9, 2015·Journal of the American Medical Directors Association·Kenneth RockwoodSusan E Howlett
Sep 9, 2015·Neuroscience and Biobehavioral Reviews·Eric A Rae, Richard E Brown
Sep 11, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hirad A FeridooniSusan E Howlett

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Mechanisms of Ageing and Development
Arnold Mitnitski, Kenneth Rockwood
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Arnold MitnitskiKenneth Rockwood
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
W GogginsSuzanne C Ho
© 2022 Meta ULC. All rights reserved