Changing biochemical presentation of primary hyperparathyroidism.

Langenbeck's Archives of Surgery
Martin AlmquistErik Nordenström

Abstract

Patients with primary hyperparathyroidism, pHPT, present with milder symptoms than previously. Some, but not all studies, suggest that this change in clinical pattern also implies lower preoperative parathyroid hormone (PTH) and/or calcium levels and smaller adenomas. This is important since reports indicate that smaller adenomas are more difficult to detect on preoperative imaging, possibly increasing the risk of surgical failure. There were 640 patients with histologically confirmed single-gland pHPT identified in a prospectively collected database. Median values of preoperative calcium, PTH, as well as adenoma weight were compared in three different time periods: 1990-1995, 1996-2000, and 2000-2007. Correlation between the preoperative levels of calcium and PTH and adenoma weight was calculated. Preoperative ionized calcium decreased significantly over time (p < 0.001). There was a positive correlation between preoperative PTH and adenoma weight (r = 0.32, p < 0.001). The magnitude of this correlation decreased over time. In women, adenoma weight decreased significantly over time (p = 0.03). Median (25th-75th percentile) adenoma weight in women was 750 (400-1,380) mg, 650 (350-1,205) mg, and 520 (305-1,065) mg in the first, ...Continue Reading

References

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Jul 11, 2009·Langenbeck's Archives of Surgery·Radu MihaiPer Hellman

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Citations

Aug 17, 2010·Langenbeck's Archives of Surgery·Bruno Niederle
May 4, 2011·Annals of Surgical Oncology·Amanda L AminTina W F Yen
Mar 29, 2012·Endocrine-related Cancer·Luqman SulaimanJamileh Hashemi
Feb 11, 2014·World Journal of Surgery·Kelly L McCoySally E Carty
Sep 20, 2012·Journal of the Chinese Medical Association : JCMA·Jeffrey Roizen, Michael A Levine
Aug 25, 2015·Clinical Endocrinology·Salvatore MinisolaJessica Pepe
Nov 16, 2016·The British Journal of Radiology·Michael Ljungberg, P Hendrik Pretorius
Jun 16, 2017·Clinical Endocrinology·K V S Hari Kumar, S K Patnaik
Aug 18, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Sumit SharmaSudhaker D Rao
Jan 3, 2018·Langenbeck's Archives of Surgery·Mark ThierMartin Almquist
Nov 19, 2015·World Journal of Surgery·Mark ThierMartin Almquist
Apr 13, 2021·The British Journal of Surgery·M NilssonM Almquist
Apr 11, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Elif HindiéDavid Taïeb

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