Changing calcium: CRAC channel (STIM and Orai) expression, splicing, and posttranslational modifiers

American Journal of Physiology. Cell Physiology
Barbara A Niemeyer

Abstract

A wide variety of cellular function depends on the dynamics of intracellular Ca(2+) signals. Especially for relatively slow and lasting processes such as gene expression, cell proliferation, and often migration, cells rely on the store-operated Ca(2+) entry (SOCE) pathway, which is particularly prominent in immune cells. SOCE is initiated by the sensor proteins (STIM1, STIM2) located within the endoplasmic reticulum (ER) registering the Ca(2+) concentration within the ER, and upon its depletion, cluster and trap Orai (Orai1-3) proteins located in the plasma membrane (PM) into ER-PM junctions. These regions become sites of highly selective Ca(2+) entry predominantly through Orai1-assembled channels, which, among other effector functions, is necessary for triggering NFAT translocation into the nucleus. What is less clear is how the spatial and temporal spread of intracellular Ca(2+) is shaped and regulated by differential expression of the individual SOCE genes and their splice variants, their heteromeric combinations and pre- and posttranslational modifications. This review focuses on principle mechanisms regulating expression, splicing, and targeting of Ca(2+) release-activated Ca(2+) (CRAC) channels.

References

Feb 13, 2007·The Journal of Biological Chemistry·Yousang GwackAnjana Rao
Apr 25, 2007·The Journal of Biological Chemistry·Wayne I DeHavenJames W Putney
Apr 19, 2008·The Journal of Biological Chemistry·Shenyuan L ZhangMichael D Cahalan
May 24, 2008·The Journal of Biological Chemistry·Rainer SchindlChristoph Romanin
Oct 15, 2008·Nature Reviews. Genetics·Alex S Flynt, Eric C Lai
Oct 22, 2009·Science Signaling·Alejandro Berna-ErroBernhard Nieswandt
Sep 30, 2010·The Journal of Experimental Medicine·Minji ByunJean-Laurent Casanova
Oct 27, 2010·PloS One·Jeffrey M KeilGentry N Patrick
Mar 9, 2011·The Journal of Biological Chemistry·Sarah J L GrahamLorna S Johnstone
May 20, 2011·Nature·Björn SchwanhäusserMatthias Selbach
Jul 20, 2011·Nature Chemical Biology·Jonathan SoboloffDonald L Gill
Jul 27, 2011·The Journal of Cell Biology·Basile DarbellayLaurent Bernheim
Jul 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Paul J Hoover, Richard S Lewis
Nov 16, 2011·The Journal of Biological Chemistry·Salvatore MancarellaDonald L Gill
Nov 24, 2011·Journal of Molecular and Cellular Cardiology·Xiang LuoJoseph A Hill
Apr 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Pulak KarAnant B Parekh
May 2, 2012·Molecular and Cellular Biology·Kotb AbdelmohsenMyriam Gorospe
Jun 12, 2012·Cell Calcium·Florian LangEkaterina Shumilina
Aug 24, 2012·Nature Reviews. Molecular Cell Biology·Jonathan SoboloffDonald L Gill
Oct 17, 2012·Biochemical and Biophysical Research Communications·Takahiro HorinouchiSoichi Miwa
Nov 20, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Salvatore MancarellaDonald L Gill
Jan 12, 2013·Molecules and Cells·Jeong-Eun LeeJoong-Kook Choi
Feb 20, 2013·The International Journal of Biochemistry & Cell Biology·Jianbiao ZhouWee-Joo Chng
Mar 1, 2013·Cardiovascular Research·Elise MerletAlexandre Marchand
Jun 28, 2013·Nucleic Acids Research·Ran ZhuangJian-Ying Wang
Jul 31, 2013·Current Topics in Membranes·Sonal Srikanth, Yousang Gwack
Jul 31, 2013·Current Topics in Membranes·Markus Hoth, Barbara A Niemeyer
Aug 3, 2013·Trends in Neurosciences·Diane LipscombeCecilia P Toro
Oct 2, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shefalee K BhavsarFlorian Lang

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Citations

Apr 23, 2017·Biochimica Et Biophysica Acta. Molecular Cell Research·Paula Nunes-Hasler, Nicolas Demaurex
Apr 14, 2017·Journal of Hypertension·Iago Méndez-LópezJ Fernando Padín
Feb 24, 2018·Nature Reviews. Drug Discovery·Tudor I OpreaGergely Zahoránszky-Köhalmi
Feb 15, 2018·The Journal of Physiology·Nicolas Demaurex, Stephanie Saul
Dec 13, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Madhuri S SalkerFlorian Lang
Sep 27, 2019·Current Drug Targets·Sampath Bhuvaneshwari, Kavitha Sankaranarayanan
Apr 8, 2017·Nature Reviews. Cancer·Gregory R MonteithSarah J Roberts-Thomson
Sep 16, 2020·Proceedings of the National Academy of Sciences of the United States of America·Derayvia GrimesRegina A Clemens
Sep 29, 2018·Cell Death & Disease·Caroline DienerEckart Meese
Aug 28, 2020·Journal of Biochemical and Molecular Toxicology·Xiaoyu LvDi Wang

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