PMID: 11902864Mar 21, 2002Paper

Changing DNA grooves--a 1,4,5,8-naphthalene tetracarboxylic diimide bis-intercalator with the linker (beta-Ala)(3)-Lys in the minor groove

Journal of the American Chemical Society
V GuelevBrent L Iverson

Abstract

We have been investigating a modular, threading DNA polyintercalator design based upon the 1,4,5,8-naphthalene tetracarboxylic diimide (NDI) intercalating unit. Previously, we have reported the NMR analysis of a bis-intercalator-DNA complex in which the peptide linker between NDI units was found to occupy the DNA major groove (Guelev, Lee, Sorey, Hoffman, Iverson, Chem. Biol. 2001, 8, 415-425). Here we describe the NMR analysis of a complex between a related bis-intercalator known to display altered DNA sequence specificity. In this case, the linker resides in the DNA minor groove. We have thus shown that within this set of sequence specific bis-intercalators, both DNA grooves can be accessed, setting the stage for longer threading polyintercalators designed to have linkers occupying both grooves in an alternating fashion.

Citations

Nov 14, 2006·Journal of the American Society for Mass Spectrometry·Carolyn L MazzitelliJennifer S Brodbelt
Feb 25, 2009·Journal of the American Chemical Society·Yongjun ChuBrent L Iverson
Feb 2, 2018·Chemistry : a European Journal·Shibaji BasakHeinz-Bernhard Kraatz
Oct 24, 2009·The Journal of Organic Chemistry·Filippo DoriaMauro Freccero
Aug 29, 2003·Organic Letters·Joseph B CarrollVincent M Rotello
Sep 25, 2007·The Journal of Organic Chemistry·Cornelia Röger, Frank Würthner
Aug 22, 2009·Journal of the American Chemical Society·Marco Di AntonioMauro Freccero
Aug 8, 2013·Journal of the American Chemical Society·Amy Rhoden Smith, Brent L Iverson
May 5, 2012·Biochemistry·Amy Rhoden SmithBrent L Iverson
Oct 28, 2004·Journal of the American Chemical Society·Jeeyeon LeeBrent L Iverson
Feb 1, 2007·Journal of the American Chemical Society·Yongjun ChuBrent L Iverson
Aug 26, 2006·The Journal of Organic Chemistry·Paolo PengoJeremy K M Sanders
Apr 1, 2004·Journal of the American Chemical Society·Bindu AbrahamLisa A Kelly
Sep 26, 2007·The Journal of Organic Chemistry·Marco Di AntonioMauro Freccero

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