PMID: 8953469Dec 1, 1996Paper

Changing effect of i.c.v. IL-1 beta on vasopressin release in anaesthetized, female rats at different stages of lactation: role of prostaglandins and noradrenaline

Journal of Neuroendocrinology
B C WilsonA J Summerlee

Abstract

Interleukin-1 beta stimulates oxytocin and vasopressin release in conscious, male rats and causes a rise in blood pressure. These experiments were done to : A) examine the effect of i.c.v. interleukin-1 beta (1 ng/microliter) on circulating levels of vasopressin in female rats at different stages of lactation and B) determine if alpha-adrenergic mechanisms and/or prostaglandins were involved as mediators. Urethane-anaesthetized nonlactating rats and rats at Day 7, 10, 20 and 26 of lactation were set up for arterial blood sampling and i.c.v. injections. One mL blood samples were obtained in one min periods before, and at 1, 2.5, 5, 10, 30, 60 and 120 min after the following treatments: i.c.v. treatment with either interleukin-1 beta (1 ng in 1 microliter PBS-BSA) or PBS-BSA (1 microliter) as a vehicle control; or i.c.v. treatment with interleukin-1 beta following pretreatment with either phentolamine (1.7 micrograms/microliter i.c.v.) or indomethacin (1 microgram/microliter i.c.v.). As blood was sampled, isotonic saline was infused (1 mL per min) and blood pressure was monitored to minimize any hypovolemic effects due to sampling. Extracted plasma was assayed using a specific vasopressin radioimmunoassay. Interleukin-1 beta i.c....Continue Reading

References

Feb 14, 1991·Biochemical and Biophysical Research Communications·Y NaitoH Imura
Dec 1, 1987·Neuroendocrinology·D A Carter, S L Lightman
Jun 1, 1985·The Journal of Endocrinology·T HiguchiK Wakabayashi
Apr 1, 1995·The European Journal of Neuroscience·R LandgrafQ J Pittman

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Citations

May 5, 2000·Experimental Physiology·I ShibuyaH Yamashita
Nov 19, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yassar ChakfeCharles W Bourque
Dec 31, 1998·Journal of Neuroendocrinology·V Sutarmo SetiadjiH Yamashita
Jul 18, 2018·Frontiers in Endocrinology·Collin J ByrneT C Tai
Oct 29, 1998·The American Journal of Physiology·C R Plata-SalamánE Satinoff
Oct 2, 1998·The American Journal of Physiology·C R Plata-SalamánE Satinoff

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