Changing epidemiology of intentional antidepressant drug overdose in Victoria, Australia

The Australian and New Zealand Journal of Psychiatry
Anselm WongJeff Robinson

Abstract

To determine the epidemiology of intentional antidepressant drug overdose (OD), over an extended time period, in Victoria, Australia. Retrospective epidemiological study of all cases reported to the Victorian Emergency Minimum Dataset (VEMD) January 1998 to December 2007 and calls to the Victorian Poisons Information Centre (VPIC) June 2005 to September 2008. 5467 VEMD cases were analysed. 3169 (57.9%) cases involved selective serotonin reuptake inhibitors (SSRIs) and 1149 (21%) involved tricyclic antidepressants (TCAs). Sertraline (1252, 22.9% cases) was the most common drug. During 2001, the peak year of OD, there were 8.8 OD/100 000 population in the SSRI group and 3.8 OD/100 000 population in the TCA group. Trends over the study period showed increasing SSRI and 'other' newer antidepressant prescription rates and decreases for TCA and monoamine oxidase inhibitors (MAOI). However, the risks of OD in all drug classes were similar and OD/100 000 prescriptions trended downwards for all drug classes over time. 1833 VPIC calls were analysed. Calls relating to SSRIs were the most common yet SSRI OD was associated with significantly fewer symptoms (p < 0.001) and fewer patients with Poisoning Severity Score classifications of moder...Continue Reading

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Citations

Aug 27, 2014·Basic & Clinical Pharmacology & Toxicology·Sébastien BeauneBruno Mégarbane
Feb 5, 2015·Depression Research and Treatment·Nastaran Eizadi-MoodAli Mohammad Sabzghabaee
Jul 6, 2014·Psychology & Health·Cathy O'MullanP J Matt Tilley
Apr 9, 2019·Therapeutic Advances in Psychopharmacology·Emma TayRichard O Day
Feb 8, 2019·Behavioral Sciences & the Law·Kenneth R ConnerKimberly Kaukeinen
Aug 2, 2017·Injury Epidemiology·Joanne E BradyGuohua Li
Mar 12, 2017·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Evan S SchwarzJeffrey Brent

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Software Mentioned

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