Changing epidemiology of motor neurone disease in Scotland

Journal of Neurology
Danielle J LeightonCARE-MND Consortium

Abstract

Scotland benefits from an integrated national healthcare team for motor neurone disease (MND) and a tradition of rich clinical data capture using the Scottish MND Register (launched in 1989; one of the first national registers). The Scottish register was re-launched in 2015 as Clinical Audit Research and Evaluation of MND (CARE-MND), an electronic platform for prospective, population-based research. We aimed to determine if incidence of MND is changing over time. Capture-recapture methods determined the incidence of MND in 2015-2016. Incidence rates for 2015-2016 and 1989-1998 were direct age and sex standardised to allow time-period comparison. Phenotypic characteristics and socioeconomic status of the cohort are described. Coverage of the CARE-MND platform was 99%. Crude incidence in the 2015-2017 period was 3.83/100,000 person-years (95% CI 3.53-4.14). Direct age-standardised incidence in 2015 was 3.42/100,000 (95% CI 2.99-3.91); in 2016, it was 2.89/100,000 (95% CI 2.50-3.34). The 1989-1998 direct standardised annual incidence estimate was 2.32/100,000 (95% CI 2.26-2.37). 2015-2016 standardised incidence was 66.9% higher than Northern European estimates. Socioeconomic status was not associated with MND. Our data show a chan...Continue Reading

References

Feb 1, 1982·Muscle & Nerve·S M Holloway, A E Emery
Feb 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·R J DavenportC P Warlow
Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·B R BrooksUNKNOWN World Federation of Neurology Research Group on Motor Neuron Diseases
Nov 5, 2003·The Journal of Behavioral Health Services & Research·Jeffrey A AlexanderCynthia I Campbell
Feb 13, 2004·Age and Ageing·Raeburn B ForbesUNKNOWN Scottish ALS/MND Register
Oct 31, 2006·Biochimica Et Biophysica Acta·Ettore BeghiUNKNOWN EURALS Consortium
Apr 11, 2007·Journal of Neurology·Raeburn B ForbesRobert J Swingler
Jun 17, 2010·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Colette DonaghyVictor Patterson
Dec 21, 2010·Lancet·Roy MaxwellJulia Verne
May 31, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Mark H B HuismanLeonard H van den Berg
Jul 8, 2011·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Eleni GeorgoulopoulouJessica Mandrioli
Nov 1, 2011·Acta Neurologica Scandinavica·P Joensen
Jun 21, 2013·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Sharon AbrahamsThomas H Bak
Oct 16, 2013·Nature Reviews. Neurology·Ammar Al-Chalabi, Orla Hardiman
Feb 2, 2015·Lancet Neurology·Jonathan D RohrerJason D Warren
Dec 22, 2015·Seminars in Nuclear Medicine·Laura B EisenmengerJames M Mountz
Jun 12, 2016·Molecular and Cellular Probes·Elaine M ClearyJon P Warner
Jul 4, 2016·Journal of Neurology·Katy TobinOrla Hardiman
Jul 12, 2016·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Carlo ScialòClaudia Caponnetto
Aug 12, 2016·Nature Communications·Karissa C ArthurBryan J Traynor
Oct 16, 2016·Neurology·Andrea L RobertsMarc G Weisskopf
Jan 17, 2017·Neurobiology of Aging·Holly A BlackSiddharthan Chandran
Feb 22, 2017·Journal of Neurology·Angela RosenbohmUNKNOWN ALS Registry Study Group
Mar 13, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Orla HardimanJames Rooney
May 22, 2017·Neuroepidemiology·Christiana A DemetriouEleni Zamba-Papanicolaou
Jul 12, 2017·JAMA Neurology·Adriano ChiòUNKNOWN Piemonte and Valle d’Aosta Register for ALS (PARALS)
Apr 25, 2018·European Journal of Epidemiology·Benoît MarinGiancarlo Logroscino

❮ Previous
Next ❯

Citations

Jul 31, 2019·Current Opinion in Neurology·Elisa Longinetti, Fang Fang
Jun 26, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Caterina BendottiEttore Beghi
Sep 18, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Sarah Opie-MartinAmmar Al-Chalabi
Sep 6, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F HenningB Marin
Sep 15, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Hilmi UysalMehmet Aktekin
Sep 9, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·HIlmi UysalMamede De Carvalho
Jul 17, 2020·Acta neurologica Belgica·Dilcan KotanA Nazlı Başak
Jan 12, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Dongqing GuGuodong Liu
May 27, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Stella A GlasmacherUNKNOWN CARE-MND Consortium
Aug 3, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Elisabetta PupilloUNKNOWN Slalom Group#
Apr 28, 2020·Journal of the Neurological Sciences·Anna Caroline BragaFranclo Henning
Nov 9, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Gavin McCluskeyStephanie Duguez
Jan 21, 2022·Annals of Clinical and Translational Neurology·Malan JohansenMaria Skaalum Petersen
Feb 2, 2022·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Judith M BurchardtJulia Hippisley-Cox

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Colette DonaghyVictor Patterson
Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Colette DonaghyVictor Patterson
© 2022 Meta ULC. All rights reserved