Changing incidence and survival in patients with aids-related non-Hodgkin's lymphomas in the era of highly active antiretroviral therapy (HAART)

Leukemia & Lymphoma
K U ChowHans-Reinhard Brodt

Abstract

To determine role of highly active antiretroviral therapy (HAART) and additional factors in incidence and outcome of patients with AIDS-related non-Hodgkin's lymphomas (NHL) we retrospectively analyzed 257 cases of AIDS-related NHL (24 low-grade, 168 high-grade B-cell, 6 high-grade T-cell, and 59 primary CNS lymphomas (PCNSL) among 2004 patients with HIV-infection treated at the University Hospital of Frankfurt, Germany from January 1983 to May 1999. Data were evaluated by univariate and multivariate analyses, using overall survival as end point. Patients received CHOP-like therapy as standard treatment. Until May 1999 incidence of all diagnosed cases of NHL was decreasing (1991-94: 14.2% versus 1995-5/99: 12.8%). Mainly, the incidence of low-grade NHL and PCNSL clearly decreased whereas the incidence of high-grade B-cell NHL increased compared to all diagnosed cases of NHL (1983-86: 53.3% versus 1995-5/99: 78.6%). One-year survival probability of all screened patients with AIDS related NHL was 54%, while 5-year survival rate remained 5%. We found age <25 years, development of NHL in the years before 1990, IVDU, CD4 counts <150/microl, PCNSL as well as NHL as the AIDS index disease, to be highly significant independent predicto...Continue Reading

References

Apr 6, 1991·Lancet·V BeralH Jaffe
Jul 28, 1990·Lancet·C S Rabkin, J J Goedert
Jan 1, 1990·Pediatric Radiology·P du LacJ Padovani
Apr 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I A CooperF C Firkin
Apr 30, 1994·BMJ : British Medical Journal·U TirelliA Carbone
Aug 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E VaccherA Carbone
Mar 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ReniE Villa
Nov 5, 1997·Current Opinion in Oncology·D J Straus
Nov 5, 1997·Current Opinion in Oncology·B Tan, L Ratner
Mar 21, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Y BlayP Biron
Jul 4, 1998·Lancet·J J GoedertR J Biggar
Nov 4, 1998·Current Opinion in Oncology·B Klencke, L Kaplan
Dec 3, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J KerstenM H van Oers
Jun 3, 1999·British Journal of Haematology·P CampbellD Joshua
Sep 24, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M BowerB G Gazzard

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Citations

Apr 15, 2006·The Cancer Journal·Joachim M Baehring, Fred H Hochberg
Mar 1, 2003·Journal of Clinical Pathology·C BellanL Leoncini
Dec 1, 2006·Neurosurgical Focus·April F Eichler, Tracy T Batchelor
Sep 11, 2013·North American Journal of Medical Sciences·Nagesh Tatero SirsathGovind Babu Kanaka Setty
Oct 1, 2016·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Rakesh ReddyRanjit Sahoo
Mar 29, 2002·Cancer·Gitty A C van der SandenUNKNOWN Working Group of Specialists in Neuro-Oncology in the Southern and Eastern Netherlands
May 27, 2004·Expert Review of Anticancer Therapy·Pia HartmannVolker Diehl
Oct 3, 2009·Annals of Neurology·Lisa M DeAngelis
Aug 7, 2013·Journal of Cancer Survivorship : Research and Practice·P A J VissersL V van de Poll-Franse
Oct 16, 2019·Journal of Basic Microbiology·Siriporn ChongkaeSirida Youngchim
May 16, 2015·International Journal of Cancer. Journal International Du Cancer·Mira HleyhelUNKNOWN FHDH-ANRS CO4
Mar 16, 2011·Deutsches Ärzteblatt International·Manfred HenselFranz Mosthaf
Dec 7, 2002·Best Practice & Research. Clinical Haematology·Mark Bower

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