Changing molecular profile of brain metastases compared with matched breast primary cancers and impact on clinical outcomes

British Journal of Cancer
A H ThomsonR Jenkins

Abstract

Breast cancer commonly metastasises to the brain, but little is known about changes in the molecular profile of the brain secondaries and impact on clinical outcomes. Patients with samples from brain metastases and matched breast cancers were included. Immunohistochemical analysis for oestrogen receptor, progesterone receptor, p27kip1, cyclin D1, epidermal growth factor receptor, insulin like growth factor 1, insulin like growth factor 1 receptor, vascular endothelial growth factor A, transforming growth factor-β and HER2 receptor was performed. Borderline HER2 results were analysed by fluorescent in situ hybridisation. Levels of expression were compared, with review of effect on clinical outcomes. A total of 41 patients were included. Of the patients, 20% had a change in oestrogen receptor or HER2 in their brain metastasis that could affect therapeutic decisions. There were statistically significant rises in brain metastases for p27kip1 (P=0.023) and cyclin D1 (P=0.030) and a fall in vascular endothelial growth factor A (P=0.012). Overall survival from the time of metastasis increased significantly with oestrogen receptor-positive (P=0.005) and progesterone receptor-positive (P=0.013) brain lesions and with a longer duration f...Continue Reading

References

Mar 26, 1999·Clinical & Experimental Metastasis·T KamalatiM R Crompton
Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·M BarbareschiR Michalides
Aug 28, 2002·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Itaru NishizukaHiroshi Shimada
Jun 5, 2004·Journal of Theoretical Biology·Stephen TurnerDavid Cameron
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jill S Barnholtz-SloanRaymond E Sawaya
Jul 20, 2004·The Journal of Pathology·Peter RegitnigSigurd F Lax
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Oct 19, 2006·Cancer Research·Zhiping LiRichard G Pestell
Jun 2, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jochen GaedckeHans H Kreipe
Jul 24, 2008·Journal of Neuro-oncology·Kan YonemoriYasuhiro Fujiwara
Feb 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joel S ParkerPhilip S Bernard
Mar 21, 2009·Journal of Cellular and Molecular Medicine·Xiaoxiang GuanMacus Tien Kuo
Aug 25, 2009·Breast Cancer Research and Treatment·Rinat YerushalmiKaren Gelmon
May 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hagen KenneckeKaren Gelmon
Nov 10, 2010·Breast Cancer Research : BCR·Alastair M ThompsonUNKNOWN Breast Recurrence in Tissues Study Group
Jul 20, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Adam M BrufskyDenise A Yardley
Aug 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin FilipitsUNKNOWN EP Investigators
Nov 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Naoki NiikuraNaoto T Ueno
Dec 6, 2011·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Takeshi ImamuraYasumichi Inoue
Aug 18, 2012·Breast Cancer Research : BCR·Renata DuchnowskaUNKNOWN Polish Brain Metastasis Consortium
Oct 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·David P KodackRakesh K Jain
Dec 12, 2012·Journal of Cancer Research and Clinical Oncology·C BachmannD Wallwiener
Dec 22, 2012·Cell Adhesion & Migration·Martine Perrot-Applanat, Melanie Di Benedetto
May 15, 2013·The American Journal of Pathology·Ina HohenseeHarriet Wikman
May 15, 2013·Breast Cancer Research and Treatment·Xiao-Ling XuWei-Min Mao
Aug 1, 2013·Acta histochemica·Larissa Bazela MaschioDebora Aparecida Pires de Campos Zuccari
Sep 6, 2013·Molecular Biology of the Cell·Jenny G ParvaniWilliam P Schiemann
Sep 17, 2013·Journal of Cancer Research and Clinical Oncology·C BachmannD Wallwiener
Dec 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Adel TabchyMatthew J Ellis
Mar 13, 2014·International Journal of Cancer. Journal International Du Cancer·Wen-Dong BaiLin-Tao Jia

❮ Previous
Next ❯

Citations

Sep 19, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Imola WilhelmIstván A Krizbai
Jun 21, 2018·International Journal of Cancer. Journal International Du Cancer·Sherise D FergusonAmy B Heimberger
Jul 3, 2018·Journal of the National Cancer Institute·Damir VarešlijaLeonie S Young
Jan 24, 2020·Neuro-oncology·Alexander F C HulsbergenMarike L D Broekman
Mar 25, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·I MeattiniO Kaidar Person
Jan 10, 2018·Journal of the National Cancer Institute·Willemijne A M E SchrijverPaul J van Diest
Nov 8, 2018·Nature Communications·Javier I J OrozcoDiego M Marzese
Apr 15, 2019·Breast Cancer Research and Treatment·Daniel N CagneyAyal A Aizer
Jul 24, 2020·International Journal of Cancer. Journal International Du Cancer·Zong-Bi YiBing-He Xu
Oct 7, 2020·Cancers·Shailendra K GautamMohd Wasim Nasser
Dec 29, 2020·Neurosurgery·Antonio DonoLeomar Y Ballester
Jun 21, 2020·Cancer Letters·Maria V BabakIrina V Balyasnikova
Feb 9, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R CostaF J Giles

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

SPSS

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.