Changing mortality risk associated with CD4 cell response to antiretroviral therapy in South Africa.

AIDS
Stephen D LawnRobin Wood

Abstract

To determine the relationship between mortality risk and the CD4 cell response to antiretroviral therapy (ART). Observational community-based ART cohort in South Africa. CD4 cell counts were measured 4 monthly, and deaths were prospectively ascertained. Cumulative person-time accrued within a range of updated CD4 cell count strata (CD4 cell-strata) was calculated and used to derive CD4 cell-stratified mortality rates. Patients (2423) (median baseline CD4 cell count of 105 cells/microl) were observed for up to 5 years of ART. One hundred and ninety-seven patients died during 3155 person-years of observation. In microltivariate analysis, mortality rate ratios associated with 0-49, 50-99, 100-199, 200-299, 300-399, 400-499 and at least 500 cells/microl updated CD4 cell-strata were 11.6, 4.9, 2.6, 1.7, 1.5, 1.4 and 1.0, respectively. Analysis of CD4 cell count recovery permitted calculations of person-time accrued within these CD4 cell-strata. Despite rapid immune recovery, high mortality in the first year of ART was related to the large proportion of person-time accrued within CD4 cell-strata less than 200 cells/microl. Moreover, patients with baseline CD4 cell counts less than 100 cells/microl had much higher cumulative mortality...Continue Reading

References

Oct 3, 2003·AIDS·Ard I van SighemUNKNOWN ATHENA Cohort Study Group
Jun 29, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louise C IversKaren Doucette
Apr 25, 2006·The Lancet Infectious Diseases·Manuel BattegayGilbert R Kaufmann
Aug 15, 2006·JAMA : the Journal of the American Medical Association·Jeffrey S A StringerMoses Sinkala
Aug 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephen D LawnRobin Wood
Jan 12, 2007·Antiviral Research·Lucjan S Wyrwicz, Leszek Rychlewski
Apr 22, 2008·The Journal of Infectious Diseases·Rochelle P WalenskyUNKNOWN CEPAC-International Investigators

❮ Previous
Next ❯

Citations

Aug 11, 2010·Archives of Internal Medicine·Eran BendavidDouglas K Owens
Oct 4, 2011·Transactions of the Royal Society of Tropical Medicine and Hygiene·Johan van Griensven, Sopheak Thai
Oct 21, 2011·The New England Journal of Medicine·François-Xavier BlancUNKNOWN CAMELIA (ANRS 1295–CIPRA KH001) Study Team
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Brian G WilliamsChristopher Dye
Apr 20, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gabriel ChamieDiane V Havlir
Oct 15, 2010·The Journal of Infectious Diseases·UNKNOWN Phidisa II Writing Team for Project PhidisaDuma Qolohle
Apr 8, 2011·AIDS Patient Care and STDs·Heather B JaspanCatherine Orrell
May 21, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephen D Lawn, Robin Wood
May 15, 2010·AIDS·Ard I van SighemUNKNOWN ATHENA national observational cohort study
Nov 19, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Mweete D NglaziLinda-Gail Bekker
Feb 8, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Richard C WatersJohn A Crump
Sep 29, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sophia PathaiStephen D Lawn
Jan 1, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Delphine GabillardUNKNOWN ANRS 12222 Morbidity Mortality Study Group
Apr 26, 2012·BMC Infectious Diseases·Alexandre GrangeiroJulio Cesar Rodrigues Pereira
Jan 20, 2011·AIDS Research and Therapy·Alan R LifsonUNKNOWN Infectious Disease Clinical Research Program (IDCRP) HIV Working Group
Sep 25, 2012·AIDS Research and Therapy·Madhuri ThakarRamesh Paranjape
Feb 2, 2011·PloS One·Alexandre GrangeiroEuclides Ayres de Castilho
Aug 21, 2012·PloS One·Trinh DuongUNKNOWN Program for HIV Prevention and Treatment Study Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.