Changing patterns in the frequency of Hodgkin lymphoma subtypes and Epstein-Barr virus association in Taiwan

Cancer Science
Kung-Chao ChangIh-Jen Su

Abstract

Epstein-Barr virus (EBV) infection is a risk factor for Hodgkin lymphoma (HL). To test whether the frequency of HL subtypes and their association with EBV has shifted with rising socioeconomic status in Taiwan, we compared the pathological features and EBV status, detected by in situ hybridization, of HL diagnosed between 1996 and 2007 (99 cases) and 1982 and 1995 (74 cases). The male-to-female ratio was 121:52 (2.3:1) and the mean age at presentation was 41.5 years. The overall EBV positivity rate was 50% (86/173 cases). Comparing the distribution of HL cases diagnosed at two different time periods, we found an increased frequency of the nodular sclerosis (NS) subtype (53 vs 68%, P = 0.045), a decreased frequency of the mixed cellularity subtype (35 vs 13%, P < 0.001), a reduced male-to-female ratio (2.9:1 compared to 1.4:1) and mean age (42.4 vs 36.6 years) in the NS subtype, and a significant decrease in EBV positivity rates among the NS and lymphocyte-depletion subtypes (61 vs 39%, P = 0.03). These data indicate shifts in the frequency of histological subtype and EBV association for HL in Taiwan over the last decade, with a trend closer to that seen in Western countries and Japan.

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Citations

Jun 1, 2011·Journal of Hematopathology·Josée AudouinDennis D Weisenburger
Nov 22, 2013·The American Journal of Dermatopathology·Angel Fernandez-Flores
Nov 26, 2010·Orvosi hetilap·Zsófia MiltényiArpád Illés
Jan 30, 2014·Hematology/oncology and Stem Cell Therapy·Maher A SughayerHanood Abu-Rass
Jul 6, 2016·Annals of Hematology·Myriam Ben DhiabMounir Trimeche
Jun 26, 2008·Journal of Experimental & Clinical Cancer Research : CR·Amos R MwakigonjaEdward M Mgaya
Jul 29, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sally L GlaserDennis D Weisenburger

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