Changing prevalence of Helicobacter pylori infection and peptic ulcer among dyspeptic Sardinian patients

Internal and Emergency Medicine
Maria Pina DoreGiovanni M Pes

Abstract

Over the past 50 years, the prevalence of Helicobacter pylori infection has fallen as standards of living improved. The changes in the prevalence of infection and its manifestations (peptic ulcer disease and gastric mucosal lesions) were investigated in a large cohort of Sardinians undergoing upper endoscopy for dyspepsia. A retrospective observational study was conducted involving patients undergoing endoscopy for dyspepsia from 1995 to 2013. H. pylori status was assessed by histology plus the rapid urease test or 13C-UBT. Gastric mucosal lesions were evaluated histologically. Data including non-steroidal anti-inflammatory drugs (NSAIDs) use and the presence of peptic ulcers were collected. The prevalence of H. pylori was calculated for each quartile and for each birth cohort from 1910 to 2000. 11,202 records were retrieved for the analysis (62.9% women). The overall prevalence of H. pylori infection was 43.8% (M: 46.6% vs. F: 42.0%; P = 0.0001). A dramatic decrease in the prevalence of infection occurred over the 19-year observation period. The birth cohort effect was evident in each category (quartile) reflecting the continuous decline in H. pylori acquisition. Over time, the prevalence of peptic ulcers also declined, result...Continue Reading

References

Jul 2, 1999·Digestive Diseases and Sciences·M P DoreG Realdi
Jun 28, 2000·Nutrition·M P DoreG Realdi
Jul 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maria P DoreGiuseppe Realdi
May 3, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M P Dore, D Vaira
Sep 24, 2005·Helicobacter·Shogo Kikuchi, Maria P Dore
Nov 16, 2005·Gastroenterology·Nicholas J Talley, UNKNOWN American Gastroenterological Association
Mar 27, 2007·Best Practice & Research. Clinical Gastroenterology·Hoda M Malaty
Sep 28, 2010·QJM : Monthly Journal of the Association of Physicians·A TamuraUNKNOWN OITA-GF Study Investigators

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Citations

Jan 30, 2016·Journal of Diabetes Research·Alessandro P DelitalaMaria P Dore
Apr 22, 2016·Helicobacter·Maria P DoreGabrio Bassotti
Aug 18, 2016·Helicobacter·Riccardo VasapolliArne Kandulski
Jul 7, 2016·Scandinavian Journal of Gastroenterology·Maria Pina DoreDavid Yates Graham
Feb 1, 2017·American Journal of Physical Anthropology·Giovanni Mario PesMaria Pina Dore
Oct 19, 2017·F1000Research·Ian Beales
Dec 14, 2018·Experimental Biology and Medicine·Maria Pina DoreGiuseppe Realdi
Feb 25, 2017·International Journal of Public Health·Giovanni Mario PesMaria Pina Dore
Jan 18, 2020·Journal of Clinical Medicine·Maria Pina DoreGiovanni Mario Pes
Oct 22, 2019·Scandinavian Journal of Gastroenterology·Maria Pina DoreGiovanni Mario Pes
Dec 2, 2020·International Journal of Environmental Research and Public Health·Pietro FerraraLorenzo Giovanni Mantovani

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