Changing profile of rotavirus in Ireland: predominance of P[8] and emergence of P[6] and P[9] in mixed infections

Journal of Medical Virology
G LennonH O'Shea

Abstract

Six hundred and thirty three fecal specimens were collected from patients under 6 years, suffering from non-bacterial, putative viral gastroenteritis in the south of Ireland, between 2003 and 2006. Following laboratory identification of rotavirus as the aetiological agent in 558 specimens, reverse transcriptase polymerase chain reaction was employed to amplify the VP7 and VP4 gene segments of 249 and 245 samples, respectively. G and P typing was subsequently carried out on these amplicons. G1 (65.1%), and G3 (16.1%) were found to be the most prevalent circulating G types over the course of the study. Both G2 (1.2%) and G9 (3.6%), were also found to be circulating, however, these types were less frequently detected. Mixed G type infections were found to account for 41 samples (14%). P typing was carried out on 245 samples. P[8] was the most commonly detected P type over the course of the study (93.5%). Both P[6] and P[9], which had not previously been detected in the Irish population, were detected during this investigation. P[6] was detected in both single and mixed P type infections, while P[9] was detected as part of mixed infections only. The key findings of this study were the emergence of P[6] and P[9] as epidemiologically...Continue Reading

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Citations

Mar 11, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Z MladenovaUNKNOWN Rotavirus Study Group
Mar 11, 2010·Virus Genes·Kamruddin AhmedOsamu Nakagomi
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Jul 15, 2011·Microbiology and Immunology·Sanghun ParkHyunsoo Kim
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Nov 6, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Aksara ThongprachumHiroshi Ushijima
Jan 25, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ritu Arora, Shobha D Chitambar
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Jul 29, 2010·Veterinary Research·Patrick J CollinsHelen O'Shea
Jun 27, 2019·Journal of Medical Microbiology·Haifa BennourAbdelhalim Trabelsi

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