Changing susceptibility of Pseudomonas aeruginosa isolates from cystic fibrosis patients with the clinical use of newer antibiotics.

Antimicrobial Agents and Chemotherapy
J A BossoJ M Matsen

Abstract

To detect a change in antibiotic susceptibility patterns in Pseudomonas aeruginosa isolates upon the introduction and clinical use of ciprofloxacin, aztreonam, and ceftazidime, MICs for clinical isolates collected before introduction of the antibiotics, during early clinical use, and later were determined for these and seven other antipseudomonal antibiotics. Concomitant resistance to two or more antibiotics was also studied. Over the three study periods, rates of susceptibility to 9 of the 10 antibiotics decreased. The largest decrease occurred with ceftazidime. Analysis of subsets of isolates from patients treated with ciprofloxacin or aztreonam also showed declining susceptibility to the latter but a stabilization of susceptibility to the former after an initial decline. Concomitant resistance within and among antibiotic classes was common.

References

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Citations

May 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E BingenJ Elion
Jul 1, 1989·Diagnostic Microbiology and Infectious Disease·N X Chin, H C Neu
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Nov 19, 2010·BMC Veterinary Research·Yasuko HirakawaHiromi Amao
Nov 26, 2009·PloS One·Jean-Paul PirnayDaniel De Vos
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Apr 1, 1993·Journal of Clinical Microbiology·G Y LarsenJ L Burns

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