Changing the composition of buffered eye-drops prevents undesired side effects

The British Journal of Ophthalmology
Norbert F SchrageMartin Reim

Abstract

The Ex Vivo Eye Irritation Test (EVEIT) is used to analyse the clinical observations of corneal calcification attributed to the presence of phosphate within applied eye-drops used in treating glaucoma, Still-Chauffard syndrome, ocular burns and dry eyes. Live corneas from abattoir rabbit eyes were cultured in order to study epithelial healing following mechanical abrasion of the corneal surface combined with repeated exposure to various eye-drops. Obvious corneal calcification of the wound area along with a complete epithelial healing covering the calcified area was observed following exposure to phosphate hyaluronate eye-drops. Epithelial healing without calcification was achieved using citrate hyaluronate eye-drops. Clinical observations show that topical use of artificial tears containing phosphate on injured eyes may lead to sight-threatening corneal complications. Simulation of such treatment conditions by the EVEIT convincingly demonstrates that changes in the composition of the pharmaceutically used treatments can prevent this undesired side effect. Although considerable healing was achieved during the repeated application of eye-drops, using either a phosphate or citrate buffer, only the drops containing citrate did not...Continue Reading

Citations

May 15, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·N SchrageF Spoeler
Jun 19, 2012·Expert Opinion on Drug Delivery·Priyanka PahujaPravin Pawar
Feb 27, 2016·Archivos de la Sociedad Española de Oftalmología·M de Frutos-LezaunM P Bachiller Cacho
Mar 28, 2016·Archivos de la Sociedad Española de Oftalmología·I Martínez-SoroaM P Bachiller Cacho
Apr 11, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·J L LauermannC E Uhlig
Jul 15, 2015·Journal of Glaucoma·Ralph PinheiroR Michael Dutescu
May 31, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·N WiesnerN Schrage
Mar 15, 2020·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Jaehee Jeon, Sihyun Park
Jul 1, 2021·Toxicology Reports·Markus GlaudoNorbert F Schrage

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Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Norbert F SchrageF Spoeler
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