Changing the Concept of Type 2 Diabetes: Beta Cell Workload Hypothesis Revisited

Endocrine, Metabolic & Immune Disorders Drug Targets
Yoshifumi Saisho

Abstract

Despite a number of innovations in anti-diabetic drugs and substantial improvement in diabetes care, the number of people with diabetes continues to increase, suggesting further need to explore novel approaches to prevent diabetes. Type 2 diabetes (T2DM) is characterized by beta cell dysfunction and insulin resistance. However, insulin resistance, usually a consequence of obesity, is often emphasized and the role of beta cell dysfunction in T2DM is less appreciated. This paper summarizes recent evidence showing the importance of beta cell dysfunction in T2DM and refines the "beta cell workload hypothesis", emphasizing the importance of beta cell preservation for the prevention and management of T2DM. It is hoped that this novel concept will foster a better understanding of the pathophysiology of T2DM by not only medical staff and patients with diabetes, but also the general population, and encourage more people to adhere to a healthy lifestyle, eventually resulting in "stopping diabetes".

References

Feb 1, 1988·The Journal of Clinical Investigation·K S PolonskyE Van Cauter
May 19, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·D R MatthewsR C Turner
May 3, 2001·The New England Journal of Medicine·J TuomilehtoUNKNOWN Finnish Diabetes Prevention Study Group
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Dec 28, 2002·Diabetes·Alexandra E ButlerPeter C Butler
Jan 9, 2003·Lancet·Hirohito SoneUNKNOWN Japan Diabetes Complication Study Group
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Kun Ho YoonSusan Bonner-Weir
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Rebecca L HullSteven E Kahn
Mar 29, 2005·Diabetes·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Mar 1, 2006·Diabetes Care·Robert A RitzelPeter C Butler
Dec 6, 2006·The New England Journal of Medicine·Steven E KahnUNKNOWN ADOPT Study Group
Dec 1, 2007·Endocrine Reviews·Vincent Poitout, R Paul Robertson
Dec 1, 2007·Endocrine Reviews·Décio L EizirikMiriam Cnop
Mar 4, 2008·Endocrine Reviews·Leena HaatajaPeter C Butler
Oct 18, 2008·Diabetes, Obesity & Metabolism·J RahierJ C Henquin
Apr 16, 2009·Diabetologia·M MasiniP Marchetti
Jun 11, 2009·Diabetes·Juris J MeierHenning Schrader
Sep 18, 2010·Endocrine Journal·Yoshifumi SaishoHiroshi Itoh
Jun 24, 2011·The Journal of Clinical Endocrinology and Metabolism·Ralph A DeFronzo, Muhammad A Abdul-Ghani
Jun 13, 2012·The New England Journal of Medicine·Hertzel C GersteinSalim Yusuf
Aug 10, 2012·Diabetes Care·Yoshifumi SaishoPeter C Butler
Jan 5, 2013·JAMA : the Journal of the American Medical Association·Edward W GreggUNKNOWN Look AHEAD Research Group
May 22, 2013·Diabetes Care·David M NathanUNKNOWN GRADE Study Research Group
Jun 15, 2013·The Journal of Clinical Endocrinology and Metabolism·Kinsei KouHiroshi Itoh
Jul 19, 2013·Diabetes·Ralph A DefronzoUNKNOWN ACT NOW Study
Jul 31, 2013·Lancet·Mark A AtkinsonAaron W Michels
Jan 28, 2014·The Journal of Clinical Investigation·Ele FerranniniHans-Juergen Woerle
Feb 11, 2015·Diabetes Care·Maria Rosario G AranetaWilfred Y Fujimoto

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