Changing topography of the RPE resulting from experimentally induced rapid eye growth

Visual Neuroscience
P A FlemingL D Beazley

Abstract

The retinal pigment epithelium (RPE) of the quokka wallaby. Setonix brachyurus, grows and changes throughout life. To investigate factors that determine changes in the quokka RPE, we have examined topography of this tissue in experimentally enlarged eyes. Unilateral eyelid suture was conducted at the time of normal eye opening, postnatal day (P) 110, and animals were examined at 1 or 1 1/2 years of age. The numbers and densities of RPE cells and the extent of multinucleation were compared with those in normal animals. Eyelid suture resulted in a 9.8% and 17.4% increase in retinal area at 1 and 1 1/2 years, respectively; a significant degree of myopia was associated with this enlargement. Cell density topography in experimental eyes was not the same as in controls. Cells from central retina were disproportionately larger in the experimental than control eyes. However, the RPE cell topography in sutured eyes was not the same as that of aged retinae of a similar size. Notably, in sutured eyes there was no development of the high or highest cell densities seen in equatorial and temporal central RPE in aged retinae, respectively. Furthermore, the degree of cell enlargement in peripheral regions was slight compared with that observed...Continue Reading

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Citations

Sep 8, 2012·Investigative Ophthalmology & Visual Science·Tobias DunckerFrançois C Delori
Apr 5, 2002·Journal of Comparative Psychology·K R Bonney, C D L Wynne
Aug 5, 2005·Visual Neuroscience·Jodi Rymer, Christine F Wildsoet
Mar 1, 2019·Investigative Ophthalmology & Visual Science·David TroiloLyndon Jones
Aug 26, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Danielle F W TeelLarry N Thibos

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