Changing trends in clinical AIDS presentations and survival among HIV-1-infected women

Journal of Women's Health
Manhattan CharuratWomen And Infants Transmission Study

Abstract

To profile trends of clinical AIDS-defining illness (ADI) among a cohort of human immunodeficiency virus (HIV)-infected women over a 12-year period. In a prospective evaluation of AIDS clinical presentation in the Women and Infants Transmission Study (WITS), 2255 subjects were enrolled and followed between December 1989 and June 2002 (total, 4993 person-years). Data on clinical AIDS presentation of 140 (6.2%) HIV-seropositive subjects were evaluated across three calendar periods corresponding to the use of different therapy regimens. Incidence rates (per 1000 woman-years) for AIDS and specific ADIs were compared between periods using Poisson regression methods. Incidence rates of AIDS, Mycobacterium tuberculosis, recurrent bacterial pneumonia, herpes simplex disease, esophageal/bronchial candidiasis, wasting syndrome, and neurological diseases have showed significant downward trends. Among women with ADI, the frequency of either esophageal or bronchial candidiasis as initial ADI showed an increasing trend (p(trend) = 0.03), whereas a decrease in proportion of cases with nontuberculosis mycobacterial infection (P(trend) = 0.05) was observed over the same periods. In the multivariate analysis, both the CD4+ lymphocyte count and H...Continue Reading

References

Sep 28, 1989·The New England Journal of Medicine·E E SchoenbaumG Friedland
Jan 1, 1986·Annals of Internal Medicine·A TavitianL E Rosenthal
May 21, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·M TumbarelloL Ortona
Nov 20, 1998·Lancet·H FarzadeganD Vlahov
Dec 30, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D M ForrestJ S Montaner
Apr 20, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J E KaplanJ L Jones
Jul 21, 2000·American Journal of Respiratory and Critical Care Medicine·J H SullivanR E Chaisson
Nov 7, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·D GreenspanJ S Greenspan
Nov 9, 2000·Lancet·A MocroftJ D Lundgren
Mar 10, 2001·The New England Journal of Medicine·T R SterlingT C Quinn
May 11, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·G CampisiV Margiotta
Jan 29, 2002·Journal of Epidemiology and Community Health·S J GangeUNKNOWN Women's Interagency HIV Study Collaborative Study Group
Oct 2, 2003·American Journal of Obstetrics and Gynecology·Howard MinkoffBruce Thompson

❮ Previous
Next ❯

Citations

Dec 21, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Brenda Evelin Barreto da SilvaLígia Mara Dolce de Lemos
Aug 31, 2007·The British Journal of Sociology·Keith Hayward, Dick Hobbs
Feb 8, 2006·AACN Clinical Issues·James Halloran
Jun 24, 2008·Human Reproduction·Simona FioreMarie-Louise Newell
Nov 14, 2012·Human Reproduction Update·V SavasiI Cetin
Jul 19, 2019·AIDS Care·Symone MayMadeline Y Sutton
May 20, 2014·Transactions of the Royal Society of Tropical Medicine and Hygiene·Mariza Vono Tancredi, Eliseu Alves Waldman
Aug 16, 2006·The Nursing Clinics of North America·Claire E Lindberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.