Changing trends in the clinicopathological features and clinical outcomes of medullary thyroid carcinoma

Journal of Surgical Oncology
Hyemi KwonWon Bae Kim

Abstract

The early detection of papillary thyroid cancer has contributed to the increase in the incidence and improved clinical outcomes. However, recent changes of medullary thyroid carcinoma (MTC) over time remain unclear. We evaluated changes of the clinicopathological characteristics and clinical outcomes in patients with MTC in recent years. A total of 109 MTC patients were classified based on the year of initial surgery: 1996-2000 (n = 14), 2001-2006 (n = 39), and 2007-2011 (n = 56). The primary tumor size significantly decreased and the proportion of microMTCs (size ≤1 cm) increased over time (P = 0.002 and P < 0.001, respectively). The proportion of patients with cervical lymph node (LN) metastasis significantly decreased (P = 0.037), and the ratio of metastatic LNs significantly decreased (P = 0.011). Disease-free survival (DFS) rate of patients was significantly improved over time (P = 0.007). There was no significant difference in DFS between microMTC and macroMTC patients. However, more advanced LN stage patients demonstrated more recurrences (P < 0.001). Especially, there were significantly more recurrences in patients with N1b diseases in comparison with patients without cervical LN metastases (P < 0.001). The prognosis of...Continue Reading

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Citations

Jun 15, 2016·Expert Opinion on Drug Safety·Venessa H M TsangDiana L Learoyd
Jun 24, 2016·European Journal of Endocrinology·Andreas Machens, Henning Dralle
Feb 7, 2018·Thyroid : Official Journal of the American Thyroid Association·Dania HirschSimona Grozinsky-Glasberg
Dec 23, 2017·Endocrinology and Metabolism·Tae Yong Kim, Young Kee Shong
Mar 14, 2019·Current Opinion in Oncology·Venessa H M Tsang
Mar 25, 2019·Langenbeck's Archives of Surgery·Francesca TorresanMaurizio Iacobone
Aug 17, 2020·Nuclear Medicine Communications·Meghana PrabhuChandrasekhar Bal
Jul 10, 2021·Annals of Surgical Oncology·Hyunju ParkJee Soo Kim

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