Changing Trends in the Management of Esthesioneuroblastoma: Irish and International Perspectives

Journal of Neurological Surgery. Part B, Skull Base
Robbie S R WoodsPeter D Lacy

Abstract

Objectives  Evaluation of the changing trends in esthesioneuroblastoma in an Irish context and review of management options nationally to clarify the best current therapeutic approach by comparing with international research on this uncommon malignancy. Design  Retrospective review. Setting  Tertiary referral center. Participants  All patients presenting with esthesioneuroblastoma in Beaumont hospital or on the National Cancer Registry of Ireland between 1994 and 2013. Main Outcome Measures  Recurrence-free and overall survival. Results  During the study period, 32 cases of esthesioneuroblastoma were diagnosed (0.4 per million per year). Average age at diagnosis was 57 years; however, two cases were under 20. The majority (62.5%) were male. Patients predominantly presented with epistaxis or nasal congestion (73%), while two cases were identified incidentally on radiological investigations. Twenty-seven cases underwent primary surgical management (two post neo-adjuvant treatment) with seventeen requiring bifrontal craniotomy. Twenty-four of these received postoperative radiation therapy. Overall, 5-year survival was 65%. Kadish A/B patients exhibited 100% 5-year disease-specific survival versus 54% in Kadish C/D ( p  = 0.011). H...Continue Reading

Citations

Jun 30, 2019·International Forum of Allergy & Rhinology·Khodayar GoshtasbiEdward C Kuan
Dec 16, 2021·International Forum of Allergy & Rhinology·Khodayar GoshtasbiEdward C Kuan

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