Abstract
The widespread use of 7-valent pneumococcal conjugate vaccine (PCV7) has changed acute otitis media (AOM) bacteriology. Only scattered data with regard to this effect of PCV13 have been published so far. We retrospectively identified children <6 years of age who presented to our hospital with AOM, and had middle ear fluid (MEF) cultures obtained during tympanocentesis or from spontaneous otorrhea during 2008-2013, when PCV7 (2009) and PCV13 (2010) were gradually introduced in the Israeli National Immunization Program. Data were extracted for demographics, clinical and microbiologic parameters, according to vaccination status. Of the 295 eligible AOM episodes reported in 279 children, 224 (76%) had MEF cultures from tympanocentesis and 71 (24%) from spontaneous otorrhea. Boys and children <2 years of age contributed 178 (60%) and 219 (74%) AOM episodes, respectively. Acute mastoiditis complicated 58 (20%) of these episodes. None of the children were PCV immunized in 2008, but >90% had received ≥1 PCV dose(s) by 2011 or later. Of the 106 (36%) MEF cultures which tested positive for otopathogens, Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and multiple bacteria grew in 60 (57%), 39 (37%), 2 (2%) and 5 (...Continue Reading
References
Sep 14, 2004·The Pediatric Infectious Disease Journal·Janet R Casey, Michael E Pichichero
May 3, 2006·Pediatrics·Krystal RevaiTasnee Chonmaitree
Sep 5, 2006·Pediatrics·Carlos G GrijalvaMarie R Griffin
Oct 31, 2006·The Pediatric Infectious Disease Journal·Robert CohenEmmanuelle Varon
Feb 5, 2008·Pediatrics·Fangjun ZhouJ Pekka Nuorti
Nov 26, 2009·The Pediatric Infectious Disease Journal·Janet R CaseyMichael E Pichichero
Feb 8, 2011·The Pediatric Infectious Disease Journal·Kostantinos StamboulidisMaria N Tsolia
Apr 19, 2011·Vaccine·Ido SomechEugene Leibovitz
Feb 14, 2012·The Pediatric Infectious Disease Journal·Sean P FitzwaterHope L Johnson
Feb 15, 2012·The Pediatric Infectious Disease Journal·Robert CohenEmmanuelle Varon
Mar 9, 2012·BMC Infectious Diseases·Robert CohenEmmanuelle Varon
May 26, 2012·The Pediatric Infectious Disease Journal·Maria C MagnusPer Nafstad
Aug 24, 2012·Expert Review of Vaccines·Birgit SimellUNKNOWN Pneumococcal Carriage Group
Sep 8, 2012·BMC Infectious Diseases·Catherine Weil-OlivierLorenzo Mantovani
Dec 26, 2012·The Journal of Infection·Aino RuoholaPentti Huovinen
Jan 23, 2013·The Pediatric Infectious Disease Journal·Thijs M A van DongenAnne G M Schilder
Feb 14, 2013·The Laryngoscope·Keyi LiuMichael E Pichichero
Mar 28, 2013·Annals of Clinical Microbiology and Antimicrobials·Lena P SetchanovaTodor Kantardjiev
Jun 28, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ron DaganDaniel A Scott
Jul 12, 2013·The Journal of Infectious Diseases·Ron DaganNoga Givon-Lavi
Jul 19, 2013·The Pediatric Infectious Disease Journal·Janet R CaseyMichael E Pichichero
Dec 18, 2013·Vaccine·Gianvincenzo ZuccottiChiara Vessia
Feb 26, 2014·Journal of the Pediatric Infectious Diseases Society·Grace M LeeJonathan A Finkelstein
Apr 3, 2014·Vaccine·Shalom Ben-ShimolRon Dagan
Jun 13, 2014·Clinical and Vaccine Immunology : CVI·Sharon Ovnat TamirTal Marom
Citations
Nov 17, 2015·The Pediatric Infectious Disease Journal·Emmanouil I KoutouzisVassiliki P Syriopoulou
Apr 21, 2016·Paediatrics & Child Health·Nicole Le Saux
Dec 16, 2016·Pediatric Emergency Care·Sharon Ovnat TamirMichal Luntz
Apr 5, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jennelle M KydRuth Thornton
Jul 23, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Helen Petousis-HarrisJennifer Griffin
May 29, 2019·The Cochrane Database of Systematic Reviews·Alexandre C FortanierRoger Amj Damoiseaux
Dec 6, 2016·The Pediatric Infectious Disease Journal·Melissa K Van DykeWilliam P Hausdorff
Apr 5, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Melinda M PettigrewTimothy F Murphy
Dec 22, 2016·The New England Journal of Medicine·Margaret A Kenna
Aug 16, 2016·BMC Infectious Diseases·Nils LittorinKristian Riesbeck
Nov 25, 2020·The Cochrane Database of Systematic Reviews·Joline Lh de SévauxRoger Amj Damoiseaux
Sep 24, 2015·The Pediatric Infectious Disease Journal·Tal MaromSharon Ovnat Tamir
Jan 18, 2020·International Journal of Pediatric Otorhinolaryngology·Mark R AldersonLea-Ann S Kirkham
Apr 25, 2021·The Journal of Pediatrics·Tal MaromJacob Pitaro