Changing trends of acute otitis media bacteriology in central Israel in the pneumococcal conjugate vaccines era

The Pediatric Infectious Disease Journal
Sharon Ovnat TamirTal Marom

Abstract

The widespread use of 7-valent pneumococcal conjugate vaccine (PCV7) has changed acute otitis media (AOM) bacteriology. Only scattered data with regard to this effect of PCV13 have been published so far. We retrospectively identified children <6 years of age who presented to our hospital with AOM, and had middle ear fluid (MEF) cultures obtained during tympanocentesis or from spontaneous otorrhea during 2008-2013, when PCV7 (2009) and PCV13 (2010) were gradually introduced in the Israeli National Immunization Program. Data were extracted for demographics, clinical and microbiologic parameters, according to vaccination status. Of the 295 eligible AOM episodes reported in 279 children, 224 (76%) had MEF cultures from tympanocentesis and 71 (24%) from spontaneous otorrhea. Boys and children <2 years of age contributed 178 (60%) and 219 (74%) AOM episodes, respectively. Acute mastoiditis complicated 58 (20%) of these episodes. None of the children were PCV immunized in 2008, but >90% had received ≥1 PCV dose(s) by 2011 or later. Of the 106 (36%) MEF cultures which tested positive for otopathogens, Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and multiple bacteria grew in 60 (57%), 39 (37%), 2 (2%) and 5 (...Continue Reading

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Citations

Nov 17, 2015·The Pediatric Infectious Disease Journal·Emmanouil I KoutouzisVassiliki P Syriopoulou
Apr 21, 2016·Paediatrics & Child Health·Nicole Le Saux
Apr 5, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jennelle M KydRuth Thornton
Jul 23, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Helen Petousis-HarrisJennifer Griffin
May 29, 2019·The Cochrane Database of Systematic Reviews·Alexandre C FortanierRoger Amj Damoiseaux
Dec 6, 2016·The Pediatric Infectious Disease Journal·Melissa K Van DykeWilliam P Hausdorff
Apr 5, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Melinda M PettigrewTimothy F Murphy
Dec 22, 2016·The New England Journal of Medicine·Margaret A Kenna
Nov 25, 2020·The Cochrane Database of Systematic Reviews·Joline Lh de SévauxRoger Amj Damoiseaux
Sep 24, 2015·The Pediatric Infectious Disease Journal·Tal MaromSharon Ovnat Tamir
Jan 18, 2020·International Journal of Pediatric Otorhinolaryngology·Mark R AldersonLea-Ann S Kirkham

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