Channel density distributions explain spiking variability in the globus pallidus: a combined physiology and computer simulation database approach

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Cengiz GünayD Jaeger

Abstract

Globus pallidus (GP) neurons recorded in brain slices show significant variability in intrinsic electrophysiological properties. To investigate how this variability arises, we manipulated the biophysical properties of GP neurons using computer simulations. Specifically, we created a GP neuron model database with 100,602 models that had varying densities of nine membrane conductances centered on a hand-tuned model that replicated typical physiological data. To test the hypothesis that the experimentally observed variability can be attributed to variations in conductance densities, we compared our model database results to a physiology database of 146 slice recordings. The electrophysiological properties of generated models and recordings were assessed with identical current injection protocols and analyzed with a uniform set of measures, allowing a systematic analysis of the effects of varying voltage-gated and calcium-gated conductance densities on the measured properties and a detailed comparison between models and recordings. Our results indicated that most of the experimental variability could be matched by varying conductance densities, which we confirmed with additional partial block experiments. Further analysis resulted ...Continue Reading

References

Jan 19, 2011·Journal of Computational Neuroscience·Eric B HendricksonD Jaeger
May 26, 2011·Journal of Computational Neuroscience·Nathan F LeporaKevin Gurney
Oct 14, 2011·Journal of Computational Neuroscience·Tomohiro FujitaKatsunori Kitano
Aug 11, 2012·Journal of Computational Neuroscience·Marco A Herrera-ValdezSharon Crook
Jan 29, 2011·Nature Neuroscience·Eve Marder, Adam L Taylor
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Eve Marder
Feb 28, 2013·Brain Connectivity·Petra RitterViktor K Jirsa
Jul 5, 2011·Integrative and Comparative Biology·Ronald L CalabreseTerrence Michael Wright
Jul 7, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Astrid A Prinz
Nov 2, 2012·Journal of Neurophysiology·Christopher A DeisterCharles J Wilson
Dec 23, 2011·Journal of Neurophysiology·Rebecca C RoffmanRonald L Calabrese
Aug 16, 2013·Journal of Mathematical Neuroscience·Robert Merrison-HortRoman Borisyuk
Aug 12, 2010·PloS One·Jenia BugaysenAlon Korngreen
Jan 26, 2012·PloS One·Hugo CornelisJames M Bower
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher A DeisterCharles J Wilson
Aug 10, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tilman J KisperskyEve Marder
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·J R EdgertonD Jaeger
Feb 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cengiz Günay, Astrid A Prinz
Jan 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nao ChuhmaStephen Rayport
Feb 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·N W SchultheissD Jaeger
May 1, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam L TaylorEve Marder
Mar 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brian J NorrisRonald L Calabrese
Jul 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·J R Edgerton, D Jaeger
Jun 26, 2014·Biological cybernetics·C Daniel MelizaHenry D I Abarbanel
Jan 28, 2009·The Journal of Physiology·Naomi KerenAlon Korngreen
Mar 2, 2012·Current Opinion in Neurobiology·Frances K Skinner
Aug 19, 2015·Journal of Computational Neuroscience·E Yu SmirnovaA V Chizhov
Jul 31, 2013·Neuroscience·C J Wilson
Feb 4, 2016·The European Journal of Neuroscience·Daniel J HegemanC Savio Chan
Aug 18, 2016·Neuroscience·Adel AlturkiSatish S Nair
Jun 25, 2016·PloS One·Alex E HadjinicolaouMichael R Ibbotson
Oct 21, 2016·Journal of Neurophysiology·Samuel A NeymotinWilliam W Lytton
Oct 31, 2017·F1000Research·Gabriele Scheler

Related Concepts

In Silico
Cataract
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